[No authors listed]
Cellular processes often depend on stable physical associations between proteins. Despite recent progress, knowledge of the composition of human protein complexes remains limited. To close this gap, we applied an integrative global proteomic profiling approach, based on chromatographic separation of cultured human cell extracts into more than one thousand biochemical fractions that were subsequently analyzed by quantitative tandem mass spectrometry, to systematically identify a network of 13,993 high-confidence physical interactions among 3,006 stably associated soluble human proteins. Most of the 622 putative protein complexes we report are linked to core biological processes and encompass both candidate disease genes and unannotated proteins to inform on mechanism. Strikingly, whereas larger multiprotein assemblies tend to be more extensively annotated and evolutionarily conserved, human protein complexes with five or fewer subunits are far more likely to be functionally unannotated or restricted to vertebrates, suggesting more recent functional innovations.
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SRB2, TRA1, MED6, CDH2, DDTL, ABI1, SRA1, UQCRFS1P1, SNRPGP15, ZNF316, LOC100132057, PDCD6IP, PDCD6, MED16, PIGK, WASH1, CHAF1A, TOM1L1, HMGXB4, RANBP9, SMC4, UBA2, SAE1, FARSB, ABCB6, ABCF2, TIMM23B, SCAMP3, DPP3, HUWE1, TSSC4, PDCD7, USH1C, PQBP1, ARPC5, ARPC4, ARPC3, ARPC1B, ACTR3, ACTR2, NUBP2, TSFM, PPIF, ARPC2, RAD50, PREB, ACTR1B, ACTR1A, RASGRP1, LRPPRC, PDIA6, TRAP1, RBM12, G3BP1, SUGP2, TRIM28, WASF2, SLC25A13, SORBS3, ALYREF, TXNDC9, CDK4, PRMT3, PSME3, MPHOSPH6, CDK5, NUTF2, EIF1, FLOT1, PSMD14, CDK7, ADAM10, PLIN3, STX6, MSLN, HNRNPR, MRPS31, TIMM17B, RIDA, POP7, SRRM1, CDK9, STAM2, SF3B4, ZMPSTE24, STUB1, UBE4B, BET1, CWC27, SAP18, SMNDC1, BCAS2, EIF1B, SF3A1, MAEA, KATNB1, TCIRG1, RTN3, LANCL1, ADAR, NPM3, HMG20B, TUBA1B, TUBB3, TUBB4B, ANAPC10, NDRG1, RACK1, NDC80, BASP1, YAP1, PRMT5, CD2BP2, UBAC1, PGRMC2, SEC24B, CFDP1, RBM14, EMG1, TIMM17A, FAM3C, ACAA2, PPIE, TOMM40, ECI2, HAX1, TACC3, SLC30A9, PPIH, COG5, TIMM44, PFDN6, TADA3, ATP5H, SLC25A17, EIF3M, NXF1, SEC23B, SEC23A, CAP1, SYNCRIP, VAT1, STK25, MYBBP1A, DDX17, CHERP, KAT5, HYOU1, IPO7, NOP56, PITRM1, SSSCA1, RNASEH2A, DCTN2, LAMTOR5, PROCR, PRDX4, ARL6IP5, ARPC1A, RPP30, SLU7, MRPL28, CCT7, CCT4, CCT2, NPC2, TACC2, DRAP1, DNPH1, SMC2, PRPF8, AHSA1, USP16, PAIP1, PAICS, PDLIM5, ERLIN1, HEXIM1, POLR3F, POLR3G, POLR3C, MYL12A, ATP5L, CENPF, EXOC5, IGF2BP1, IGF2BP3, IGF2BP2, MTX2, YKT6, PMVK, KHDRBS1, CTCF, CETN2, CCT6B, CCT8, USP39, POLD3, CFL1, NUDC, PTGES3, YME1L1, CFL2, STAG2, CTSC, GIPC1, NUP50, HBS1L, AHCYL1, SRSF10, NEK6, WDR4, MTHFD2, RPP40, SEPT9, SEC24A, HSPH1, UTP14A, CPLX1, SRCAP, CD3EAP, RUVBL2, PGRMC1, USP19, MRPS30, WDR3, RAB10, TXNL4A, SUGT1, PAPOLA, TCERG1, MAGED2, COPS8, RNPS1, SUB1, RALBP1, MORF4L1, PRDX3, EHD1, POP1, C11orf58, SF3A3, HNRNPA0, TOMM34, TMED2, LMAN2, STIP1, EBNA1BP2, TMED10, UQCR11, FERMT2, COPS6, MAPRE2, GCN1, COPS5, IMMT, SF3B2, ILVBL, SLC27A2, TLK2, ATF7, IFT27, RAB31, DSTN, RCC1, NUDT21, CPSF6, OGFR, WWP2, UBE2C, CHD3, TOPBP1, STMN2, DNAJB4, CHD4, DIDO1, WDR5, HNRNPUL1, KATNA1, CHEK1, CIT, FAF1, POLR3A, CDC37, LSM6, RABL2A, ERLIN2, NUDT5, PSIP1, WDHD1, STRAP, BAZ1A, WDR6, ABCB8, SEC23IP, SUPT16H, DDX20, MRPL3, RPL35, ZHX1, PRKCDBP, DTD2, GTF3C6, DCTN3, XPOT, SNF8, MGAT4B, PNKP, L3HYPDH, TP53RK, SGF29, VPS26B, MED8, VPS45, CDCA5, AHNAK2, PARK7, COPE, SAAL1, ECD, GPN1, C12orf57, DDX42, PHB2, CBX3, EXOC3, GABARAP, U2AF2, EXOSC8, TWF2, HELQ, TOE1, WBSCR22, PALM2, ERMAP, CHUK, VASN, CKB, CIRBP, LRRC42, MALSU1, UHRF2, TBCB, TRMT61A, CKMT1B, RMI2, FOXP4, WDR92, CKS1B, MRPL53, MRPL54, FTSJ3, AP1S1, AP3S1, EXOSC6, SFXN2, TPP1, FAT3, CLNS1A, CLPTM1, CLTC, IKBIP, MRPL52, LEO1, ZC3H18, ABCC2, OVCA2, LSM12, MRPL10, INO80C, TTC39C, RAVER1, C19orf70, TRAPPC5, CNN2, TCHHL1, COL1A1, MRPL55, CHMP4B, PIGU, TANGO2, PPP1R21, NUP35, COL7A1, DNAJC19, COPA, CHCHD4, COPB1, OCIAD2, COX5B, MROH2B, NADK2, COX6B1, LSM11, WDR36, NUDCD2, UBLCP1, COX15, MTPN, MPLKIP, CPOX, CPS1, CPT1A, TAF1L, CREB1, CRK, MYL6B, S100A16, UBE2F, RPL10L, SRXN1, SREK1, PARP1, MAPK14, PARP4, CSE1L, PSMA8, SPTY2D1, SLC2A14, CPNE8, HNRNPA1L2, CSNK1A1, CSNK1D, CSNK1E, MDP1, CSNK2A1, CSNK2A2, CSNK2B, CSPG4, CSRP2, TOM1L2, SLC25A10, WIPF2, CSTB, CSTF2, SPC24, SIX5, CSTF3, C19orf25, RC3H1, EXOC8, CTNNA1, COMMD7, CTPS1, COPS9, CTSB, CTSD, SEPT10, PPP4R2, GLIPR2, ZNF827, NFXL1, CXADR, CYC1, AMOT, RBM33, TMEM65, ADSL, ADSS, AP2A1, LDHAL6A, CD55, DENND5B, DAG1, DGKA, DGKQ, AP2A2, DARS, AP1B1, AARS, SLFN5, DBN1, DBT, ECI1, DCTN1, DDB1, AP1G1, DDOST, DDX1, DDX3X, DDX5, DDX6, RNF168, DHX8, DHX9, DHX15, DES, DFFA, DFFB, QSOX2, DHX36, COMMD6, POLR3H, DHODH, CYB5R3, NQO1, DIAPH1, DKC1, DLAT, DLD, DLST, DMD, SARDH, DNASE2, DYNC1H1, AGL, DYNC1LI2, DNM2, DPYD, DR1, DRG2, DSG2, DSP, SLC26A2, DTNA, DUT, ECE1, ECH1, AHCY, EEF1A1, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EIF2D, EGFR, EIF1AX, ZFC3H1, PLBD2, EIF2S1, EIF2S3, EPHA2, UBR1, AHSG, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4G1, EIF4G2, EIF5, EIF5A, ELAVL1, TXLNA, EMD, LRRC45, UNC13D, STT3B, PDE12, CTTN, RWDD4, ENG, ENO1, ENO3, TUBB, AK1, VMA21, EPB41L1, STOM, AK2, EPHX1, EPRS, ERCC1, ERCC2, ERCC3, ERCC4, FBL, ESD, ESRRA, ETFA, ETFB, EVPL, EWSR1, EZH2, ABCD1, ACSL3, ACSL4, BPTF, FAP, ALDH1B1, FARSA, FASN, OR4S2, FAU, MRPL21, PATL1, ORAOV1, RPLP0P6, HNRNPA3, HNRNPUL2, SKA3, CPNE2, NT5DC1, HIST1H2AA, TMED4, RSBN1L, LRWD1, ABCB7, FEN1, ALDOA, FH, COG2, FKBP1A, XRN2, COPZ1, COPG1, RASA3, HSPA4L, DNAJC8, PUF60, SCAF8, PPP6R1, SEC31A, FKBP3, MON1B, FKBP4, FOXJ3, DIS3, DHX30, RALY, NCBP2, MAPRE1, MSRB2, SEPHS2, SEPHS1, SNW1, CCT5, PTGR1, SLC4A1AP, TPX2, PAXIP1, ACIN1, SORCS3, LIMCH1, RAB21, SPEN, EXOSC7, CNOT1, SNRNP200, PALLD, ALDOC, KDM1A, KDM4B, XPO7, PDXDC1, PDS5B, FNBP1, FOXM1, NCOA6, TBC1D9B, GGA2, WAPL, EMC1, SETD1B, SWAP70, ERC1, PEG10, ZC3H13, CDK19, ZBTB43, MRPS27, AKR1B1, SMC5, FLII, WDR43, FLNA, NUP205, RTF1, TTLL12, FLNB, FLNC, LARP4B, ATG4B, FLOT2, GANAB, MDN1, FAF2, GSE1, PMPCA, ZC3H4, RRS1, XPO6, FBXO28, RRP12, SYNE2, NUP210, DNAJC9, PLCB1, PHLPP1, COBL, PDS5A, BOP1, RPRD2, SCFD1, DENND5A, PPIP5K2, ZC3H7B, EXOC7, MGA, CSTF2T, FKBP15, KIAA1033, CLASP1, VPS39, ESYT1, U2SURP, UBR4, LARP1, MAU2, NCSTN, NUDCD3, KIAA0368, ADNP, NCAPH, EXOSC2, COTL1, SIRT1, COMMD3, NOMO1, TARDBP, SF3B3, SF3B1, ABCB10, CBX5, BRD4, PES1, FOLR1, TGDS, MACF1, POFUT1, NUP188, SUZ12, SKIV2L2, SRRM2, ZNF281, NNT, TNPO3, ATP6V0A2, DNPEP, FOSL2, WBP2, SMUG1, CARHSP1, LEMD3, ORC3, CORO1C, CD2AP, ZMYND8, TSSK2, KPNA6, NUP62, POLA2, PLXNB2, LSM5, ZKSCAN5, STX12, GSPT2, FKBP8, MTCH1, MTCH2, TFIP11, PRPF6, ZNF318, CDC26, ALOX15B, FTH1, FTL, FUS, ABL1, TMEM9, FUT8, MMS22L, TTC41P, FAM21C, G6PD, EHBP1L1, XRCC6, GAA, TMEM256, GABPA, LRRC57, LOC255308, GABPB1, HIST1H2BA, RNF214, HYPK, PRPF40B, RAB3GAP2, LSM4, SAMM50, PRDX5, TXN2, NIPBL, COG4, ANAPC13, RPL36, POLR1A, POC1A, INTS7, GALNT2, NDUFAF3, THUMPD3, ZDHHC5, NOL11, GEMIN5, PTPN23, CLIC4, NSL1, HEATR5A, SIN3A, KIAA1429, GAPDH, DHRS7B, AAR2, ULK3, HIGD1A, GORASP2, TKFC, RPAP1, UPF2, PTCD1, SIPA1L1, UBXN7, RAB11FIP5, ERC2, HACL1, LSM14A, TOR1AIP1, WIPI2, PRPF31, FGFR1OP2, GAPVD1, SERBP1, TES, RSL1D1, SENP3, GARS, TIPRL, GART, PHGDH, FAM50B, HIBCH, VPS33B, ERAL1, MYCBP, GBE1, GBP1, HSPB8, GNL3, FAM162A, PPP1R14B, PLEK2, MYOF, TIMM10B, TIMM13, TIMM10, TIMM9, OSTF1, MRPL46, OR8B2, TBL2, ELP4, GDI1, GDI2, PIPSL, B4GALT1, COPG2, PABPC1, NPTN, TRMT2A, PELP1, SND1, VPS41, UQCRQ, TAF5L, CACYBP, SNX5, NDOR1, TUBGCP4, GPKOW, CHMP2A, ERLEC1, PDCD4, LSM1, LSM3, RBMXL2, CRCP, APEX2, GCLM, RBMX, RPS6KA6, ZNF638, GOLIM4, EIF3K, HTATSF1, UBE2S, PRPF19, UTP20, RRP7A, MCAT, GLO1, HTRA2, MAT2B, GMDS, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GNB1, GNL1, GOLGB1, GPD2, GPI, STK32C, TTC9C, GATC, CHAMP1, FAM98B, KANSL1, PTRF, ZNF326, UNC80, SH3PXD2B, ZNF454, SCAI, GPS1, GRB10, REM1, LAMTOR2, MRPS28, MRPS18B, ACAD9, MRPL42, IFT81, MCTS1, NTMT1, MRPL13, NDUFAF4, MED4, CHMP4A, PHPT1, BABAM1, THYN1, MRPL15, UBE2T, MRPL22, RANGRF, COMMD9, SSU72, NXT1, TAGLN3, SAP30BP, SLC25A4, RACGAP1, UHRF1, SLC25A5, PDIA3, GSK3B, SLC25A6, GSN, GSPT1, GSR, GSS, GSTP1, GSTT1, MSH6, GTF2A1, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF3C1, USP25, GTF3C2, PACSIN3, TMOD3, TMOD2, PARVB, OLA1, UQCR10, TFCP2L1, TFPT, UBN1, ANAPC2, SNX8, STRN4, RBM15B, CPSF1, TRA2A, SNX15, C18orf8, EPN1, GMPPB, GMPPA, SNX12, NENF, PKN3, ANAPC4, DPP7, CERS2, SLC25A24, STRN3, PSAT1, MDFIC, UBQLN2, UBQLN1, GLTSCR2, SH3KBP1, HIST1H1C, HIST1H1E, ANXA1, HIST1H2AD, HIST1H2BB, ANXA2, ACAA1, HSD17B10, HADHA, HADHB, HARS, HAS1, HBB, HCFC1, ANXA3, HDAC1, HDAC2, HDLBP, ANXA4, ANXA5, CXXC1, EHD4, EHD2, TAX1BP3, UBE2K, HINT1, STOML2, HK2, ANXA7, HLA-B, ANXA11, ACACA, HLA-G, HMGB1, HMGB2, HMGN1, HMGCS1, HMGA1, HNMT, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPC, HNRNPD, HNRNPF, HNRNPH1, HNRNPH2, HNRNPH3, HNRNPK, HNRNPL, HNRNPU, HOXC10, HPRT1, HRAS, AGFG1, APEH, PRMT1, HSBP1, APEX1, HSD17B4, HSF1, DNAJA1, HSPA1A, HSPA1L, HSPA2, HSPA4, HSPA5, HSPA6, HSPA8, XIAP, HSPA9, HSPB1, HSP90AA1, HSP90AA4P, HSP90AA2P, HSP90AB1, HSP90AB3P, HSPD1, HSPE1, NDST1, IARS, UBAC2, ICT1, IDH1, IDH3A, IDH3G, NACA2, HNRNPCL1, IFIT2, IGBP1, TUBB2B, IGF1R, IGF2R, NUP43, IGFBP7, APRT, IK, ILF2, ILF3, IMPDH1, IMPDH2, INPP1, INPPL1, EIF3E, ITGA2, ITGA5, ITGAV, ITGB1, ITGB4, EIF6, ITPA, ITPR3, ARCN1, ACADVL, JUP, ANOS1, KARS, NDUFS7, TMEM179B, ARF1, CYSRT1, ARF3, KIF5A, KIF5B, ACAT1, KLC1, KIF11, KPNA1, KPNB1, KPNA2, KPNA5, TNPO1, IPO5, KRT1, KRT2, KRT3, KRT5, KRT7, KRT8, KRT9, KRT10, KRT14, KRT16, KRT17, RHOA, TMEM189, KRT18, FAM21A, RHOB, COA6, SMIM20, RHOC, KTN1, RBM12B, NUDT19, LAMB1, LAMP1, HSP90AB2P, LAMP2, RPSA, ACAT2, STMN1, LBR, LCP1, LDHA, ARHGAP5, LDHB, LETM1, LGALS1, LGALS3, LGALS3BP, ARHGDIA, LIMS1, LMAN1, LMNA, LMNB1, MED11, LMO7, RGPD1, VWA5A, ARL2, LPP, TPM3P4, LTA4H, M6PR, CAPRIN1, MARCKS, SMAD5, MAN2A1, MAN2B1, MAP4, MARS, MAT1A, MAT2A, MAX, MBNL1, MBP, MCAM, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDH1, MDH2, MEA1, MECP2, RAB8A, MEN1, MET, METTL1, MFAP1, MGST3, MICB, MID1, MIF, MKI67, MLH1, KMT2A, MNAT1, MOV10, MPI, MPST, MPV17, MRE11A, ABCC1, ASNS, LOC440434, POTEKP, MSH2, MSH3, ASS1, SULT1A4, MSN, MT1A, MTHFD1, MTR, MTX1, MVK, MYH9, MYH10, MYH11, MYL1, MYL6, MYO1C, MYO1E, PPP1R12A, ATF1, NAB2, NACA, HNRNPM, NAP1L1, NAP1L4, NARS, NASP, NUBP1, NBN, NCBP1, NCL, NDUFA2, NDUFA5, NDUFA7, NEB, NDUFA9, NDUFA10, NDUFB4, NDUFB5, NDUFB6, ATIC, NDUFB7, NDUFB8, NDUFB9, NDUFB10, NDUFS1, NDUFS2, NDUFS3, NDUFV1, NDUFS4, NDUFS6, NDUFS8, NDUFV2, NDUFV3, NEDD4, SEPT2, RPL10A, NEDD8, NF2, NFIA, NFKBIE, TONSL, NFRKB, NFYA, SNU13, ACO1, NME1, NME2, NQO2, NOP2, NONO, CNOT3, NOTCH2, PNP, NPC1, NPM1, ATP2A1, ATP2A2, NPTX1, NRAS, NRDC, YBX1, NSF, NT5E, NTHL1, NUCB1, NUMA1, NUP88, OAS3, CHAC2, OAT, OGDH, OPA1, ATP5A1, ORC2, ORC5, OXA1L, OXCT1, ACO2, P4HB, PA2G4, PEBP1, SMARCAL1, PRDX1, ATP5B, MYEF2, AK3, HP1BP3, COPS7A, HEBP1, PBX1, PC, ATP5C1, PCBP1, PCBP2, PCDH7, MTERF3, TPRKB, EXOSC3, CCDC53, MRPS16, FIS1, PAM16, VPS36, UBXN1, ZNF593, TXNDC12, RPS27L, YARS2, NMD3, MRPL2, NOSIP, DERA, MRPL4, TMX2, NDUFA13, MRPS7, POLR1D, TRNT1, PCMT1, LACTB2, PCNA, MRPS2, SBDS, ZNF706, IER3IP1, NAA20, KCTD3, COPS4, CHCHD2, DYNC1LI1, MRTO4, HN1, DCTN4, HSPA14, CHMP1A, IPO11, DDX47, NUSAP1, TACO1, ACOX1, PHF20, PAIP2, MRPL37, MRPL51, MRPL30, UBAP1, ECSIT, TIMMDC1, WAC, ATP5D, SPG21, CRNKL1, ZBTB7A, UBR5, POMP, UCHL5, ATP6V1D, EIF3L, RWDD1, COMMD10, PPME1, ANAPC5, ANAPC7, PCYOX1, PDE6A, LIMA1, NOP16, RTCB, HACD3, CWC15, TRMT112, UFC1, CHMP5, LARS, TMEM14C, ATP5F1, VTA1, SIRT6, RAB14, ARMCX3, UFM1, PCF11, MED15, SRRT, CUTA, NOP58, PDHA1, METTL13, PIGT, TRMT6, ATP6V1H, GET4, PDHA2, ERGIC3, TAF9B, PDHB, LUC7L2, OTUD6B, C14orf166, SF3B6, MRPL48, FAM96B, MRPS23, PTRH2, GINS2, FKBP7, ZFR, LSM7, LSM8, CPSF3, VPS29, CYB5R1, CAB39, DNAJB11, WBP11, LUC7L3, CDK12, SIX4, PHAX, PFAS, PFDN1, PFDN2, PFDN4, PFDN5, PFKFB2, PFKL, ATP5I, PFKM, PFKP, PFN1, PFN2, ATP5J, ACP1, PGAM1, PGK1, ATP6V1A, PGM1, PGM5, PHB, SLC25A3, ATP6V1B1, PHKA1, PHKA2, PHKB, ATP6V1B2, SERPINB6, SERPINB8, ATP6V1C1, PIK3CB, ATP6V1E1, PIK3R1, PI4KA, PIN1, PIN4, PKM, PLA2G4A, ACP2, PLAUR, PLCB3, PLCG1, NUP54, PLEC, PLK1, PLOD1, ATP6V0A1, PLP2, PLRG1, PLS3, MBD3, ATP6AP1, PMM2, PMS2P1, ATP7A, ATP5O, EXOSC9, PPIL3, EXOSC10, PMS2, CPSF2, PCBP3, PNLIPRP2, POLE3, CHRAC1, SEPT5, MRPL39, NANS, CYCS, POLA1, POLD1, POLE, POLE2, POLR2A, POLR2B, POLR2C, GDAP1, POLR2D, POLR2E, POLR2G, POLR2H, POLR2I, TERF2IP, SLC38A2, GAR1, RBM27, ANLN, PON2, MRPS21, ZFAND6, TOLLIP, DGCR8, TMCO1, DHX29, EXOSC4, POU2F1, PUS7, WDR44, ATR, MRPL50, EXOC6, NDUFB11, TOMM7, DDX49, INO80, PAF1, PPA1, TBC1D13, WDR74, CROT, MED1, RRN3, PPAT, TMED9, CTSA, PPIA, DNAJB12, PPIB, MED18, PPIC, GATAD2A, ERCC6L, GON4L, FNBP1L, TEX10, NSUN2, SPDL1, YTHDF1, CHCHD3, IMPAD1, SARS2, COMMD4, OCIAD1, MRPL16, SDHAF2, COMMD8, PPM1B, PPM1G, THG1L, ULK4, PPP1CA, GID8, PPP1CB, LAMTOR1, PIH1D1, PPP1CC, PTCD3, PPP1R2, MRPL20, ZWILCH, UACA, MED9, GPATCH1, SAMD4B, WDR70, MAGOHB, PPP1R8, RBM28, SRBD1, WRAP53, ELP3, PPP1R10, UBR7, PPP2CA, SDAD1, PNPO, MRPS10, RMDN3, MRM3, PPP2R1A, RIF1, PPP2R1B, PBRM1, PPP2R2A, NAT10, LRRC1, PANK4, SMU1, UBA6, ELP2, PSPC1, PHF10, VPS53, PGM2, PPP2R5D, PPP6R3, BRIX1, PPP3CA, DDX19A, PEF1, ABCF3, SYNJ2BP, WDR33, STRBP, PPP3R1, TBC1D2, PPP5C, PPP6C, LRRC59, PPT1, PRCC, PREP, H2AFY2, HAUS7, PRIM1, CDV3, PRIM2, MED29, OTUD5, ZCCHC8, RNPC3, CDKN2AIP, LRRC16A, OTUB1, TRMT1, TTC27, PRKAA1, THUMPD1, LRRC40, PRKAB1, NHP2, INTS8, PRPF40A, DDX27, PRKACA, URGCP, NPLOC4, MFN1, PPP4R3A, PRKACB, IWS1, SCYL2, RABL6, YEATS2, NSUN5, VAC14, IARS2, POLR3B, IPO9, NECAP2, TSR1, ASF1B, ASUN, ATF7IP, PRKAR1A, VPS35, NUP133, CNDP2, SEPT11, INTS9, WDR12, PRKAR2A, EXOC2, TDP1, RIOK2, PRKCA, TXLNG, LMBRD1, CSGALNACT1, DDX28, UTP6, TSNAXIP1, VPS11, UBAP2, CISD1, PKN1, ZC3H15, ACOT13, TMEM165, ACTR10, TMEM126B, PBK, PRKCSH, UNC45A, RNF114, PRKDC, LANCL2, RCC2, DMAP1, MAPK1, MAPK3, NDUFA12, NSFL1C, GNG12, MAPK9, UBFD1, EIF2AK2, PCDHA2, YLPM1, RNF20, LRRC8A, WDR45B, PRPH, PRPS1, METTL3, PRPS2, PRPSAP1, LGMN, PRSS1, DNAJC12, PSAP, TUBB7P, PSEN1, BCCIP, POLE4, SAR1A, PSMA1, ZC3HAV1, PSMA2, PSMA3, RAD18, PSMA4, PSMA5, PSMA6, PSMA7, UGGT1, PSMB1, UBQLN4, WRNIP1, PNO1, PSMB2, SH3GLB2, IFT46, PSMB3, EXOSC5, MCCC1, PSMB4, LXN, NCLN, PSMB5, PSMB6, ENY2, MRPS22, MFF, XAB2, PRTFDC1, PSMB7, NIT2, OTUD7B, PSMB8, PSMB9, POGLUT1, PSMG2, PSMB10, TOMM22, PSMC1, PSMC2, CIAPIN1, PSMC3, PDXP, PSMC4, PSMC5, DDX24, PSMC6, PSMD1, PSMD2, PSMD3, PSMD4, TIGAR, PSMD5, GOPC, NUP107, MRPL47, PSMD7, RTN4, PSMD8, PSMD9, PSMD10, PSMD11, CORO1B, PSMD12, THOC2, PSMD13, PSME1, PSME2, ERGIC1, PPP4R3B, PTBP1, BAG1, PTGFRN, SPC25, MIF4GD, SCYL1, RHBDD2, WDR18, NDRG3, GATAD2B, ISY1, SCAF4, LRRC47, PRR12, NLN, ESYT2, ARID1B, MTA3, MAVS, INTS2, XPO5, COG6, SERINC1, HECW2, WDR35, TAOK1, TWF1, PTMA, WDFY1, ZNF687, SLAIN2, RANBP10, VPS18, SHROOM3, PTMS, EP400, USP28, DHX37, SHTN1, PTPN1, TLDC1, MIER1, PTPN2, METTL14, NCOA5, PTPN6, SUGP1, CCAR2, PTPN11, LSM2, BAK1, PURA, PURB, PTBP2, PVR, PWP2, PEX19, ABCD3, PXN, ALDH18A1, PYGB, SQRDL, SRPRB, INIP, RBM25, WIZ, SNX6, QARS, RAB1A, RAB2A, RAB5A, RAB5B, RABGGTA, RAB5C, RAC1, RAD21, RAD23A, RAD23B, RALA, RALB, RAN, RANBP1, RANBP2, RANGAP1, RAP1A, RAP1B, RARS, ACTA2, RB1, RBBP4, UBL5, RBBP5, RBBP6, RBBP7, RBM3, RBM4, RBMS1, RBMS2, RCN1, RCN2, RDX, UPF1, DPF2, RFC1, RFC2, RFC3, RFC4, RFC5, RFX5, RFXAP, ACTB, C12orf10, TSKS, EXOC4, MRPS35, NIF3L1, RNH1, RINT1, EEFSEC, FKBP10, ROBO1, RPA1, RPA2, RPA3, RPE, RPL3, RPL3L, RPL4, RPL5, RPL6, RPL7, RPL7A, RPL8, RPL9, RPL10, RPL11, RPL12, RPL13, RPL15, RPL17, RPL18, RPL18A, RPL19, RPL21, RPL22, RPL23A, MRPL23, RPL24, RPL27, RPL30, RPL27A, RPL29, RPL31, RPL32, RPL37, RPL37A, RPL38, BCS1L, RPLP0, RPLP1, RPLP2, MRPL12, RPN1, RPN2, RPS2, RPS3, RPS3A, RPS4X, RPS5, RPS6, RPS6KA2, RPS6KB2, RPS7, RPS8, RPS9, RPS10, RPS11, RPS12, RPS13, RPS14, RPS15, RPS15A, RPS16, RPS17, RPS18, RPS19, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS27A, RPS28, RPS29, RRBP1, RRM1, RRM2, S100A4, S100A6, S100A9, S100A10, S100A11, S100A13, S100P, VPS52, SAFB, MAPK12, SARS, MSMO1, ATXN2, SCP2, BID, SDC1, MRPL17, THADA, SDHA, UBE2O, VIPAS39, SDHB, CHTF18, TNN, MRPS14, CXorf56, SEC13, FIGNL1, SEL1L, MYO1G, RBM26, MCCC2, TMBIM1, ACOT1, NCAPG, SET, IRF2BPL, MMS19, SFPQ, SRSF1, SRSF2, SRSF3, SRSF4, SRSF5, SRSF6, SRSF7, XPO4, TRA2B, INF2, POLR1E, MRPS25, INTS4P2, SGSH, SGTA, SH3BGRL, BLVRB, ITSN1, SH3GL2, VPS16, ANAPC1, SHMT1, COPS7B, NUCKS1, MARC1, TNS3, IPPK, MTHFSD, RBM15, GINS3, IFT22, DDX31, KLC2, FAM129B, PAPOLG, RANBP17, SLC30A5, MRPL14, MRPS26, MRPS11, MRPS9, MRPS5, MRPL41, MRPL40, MRPL38, MRPL32, SKIV2L, SKP1, MRPL11, MRPL9, MRPL1, SKP2, MRPL44, VPS33A, SLC1A5, MARCKSL1, UPF3B, INTS3, SLC2A1, SLC3A2, SPATS2, COA7, UBE2Z, PPIAL4A, BOLA2B, SLC9A1, SLC12A2, SLC12A4, SLC16A1, SLC25A1, SMARCA1, SMARCA2, SMARCA4, ZSCAN18, SMARCB1, ZBTB10, DDRGK1, SMARCC1, MRPS34, SMARCC2, SMARCD1, SMARCD2, SMARCD3, SMARCE1, SMN1, SMN2, SMS, POLR3D, SUMO2, SNCA, SNCG, FSCN1, SNRNP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPC, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNX1, SNX2, SOAT1, SOD1, SOD2, SON, SORD, SP100, DST, UAP1, SPG7, BPGM, SPR, SPTAN1, SPTB, SPTBN1, SPTBN2, SRM, SRP9, SRP14, SRP19, SRP54, SRP68, SRP72, SRPK1, TROVE2, SSBP1, SSR1, SSR3, SSR4, SSRP1, ST13, STAT1, STAT5B, STAT6, STIM1, STK4, AURKA, STRN, STX4, STXBP1, STXBP2, STXBP3, SULT1A1, SUPT4H1, SUPT5H, SURF1, SURF4, MED22, SVIL, VAMP2, SYN1, TACC1, TAF1, TAF2, TAF4, TAGLN, TAF5, TAF6, TAF7, TAF9, TAF10, KLF5, TAF13, MAP3K7, TALDO1, TAP1, BTF3, TARS, TBCA, TBL1X, TBP, TCEA1, TCEA2, TCEB1, TCEB2, TCEB3, ZEB1, VPS72, TCOF1, TCP1, DYNLT3, DYNLT1, PRDX2, TEP1, TERF2, ACTC1, TFAP4, TFDP1, TFPI, BYSL, THOP1, THY1, TIA1, TIAL1, TJP1, C1QBP, TKT, TLE3, TLN1, TRAPPC10, TMPO, TNFAIP2, TOP1, TOP2A, TOP2B, TOP3A, TP53BP1, TPBG, TPD52, TPD52L2, TPI1, TPM1, TPM2, TPM3, TPM4, TPR, TPT1, HSP90B1, CCT3, TRIO, TRIP6, TSN, TSC2, TSG101, TSNAX, TST, TSTA3, TTC1, TTC4, TTK, TTN, TUBA4A, TUBB2A, ZBTB8B, TUBG1, TUFM, TXN, TXNRD1, TYMS, TYRO3, HSP90AA5P, U2AF1, UBA52, UBA1, UBE2A, UBE2B, UBE2D1, UBE2D2, UBE2E1, UBE2E2, UBE2G1, UBE2H, UBE2I, UBE2L3, UBE2N, UBE2V1, UBE2V2, UBE3A, SUMO1, UBP1, UBTF, UCHL1, UCHL3, UFD1L, UGDH, UGP2, UCK2, UMPS, UNG, NR1H2, UPP1, UQCRB, VPS51, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UROD, USP1, UTRN, MRPL49, VARS, VASP, VAV2, VBP1, ZNHIT2, VCL, VCP, VDAC1, VDAC2, VDAC3, EZR, VIM, VRK1, VTN, WARS, EIF4H, WHSC1, XPC, XPNPEP1, XPO1, XRCC1, XRCC4, XRCC5, YES1, YY1, YWHAB, YWHAE, YWHAZ, SF1, ZNF24, CA9, ZNF131, TRIM25, ZNF148, TRIM26, ZMYM2, ZNF207, ZFAND5, SLC30A1, ZYX, PTP4A1, CACNA2D1, DAP3, MOGS, TUBA1A, USP7, RAB7A, MRPL57, C19orf43, CAD, NUP37, AHNAK, ERI3, NABP2, ZFYVE21, NOC4L, TRPM8, METTL16, C2orf49, DSCC1, DCTPP1, UQCC3, DEK, ALDH5A1, RBM42, THTPA, TMEM43, DDX39B, THOC6, PAGR1, GCC1, CDC73, CORO7, MRPL24, SAP130, NAA16, TANGO6, RNASEH2B, AIMP2, RPAP3, DHX40, ZCCHC6, NLRX1, QTRT2, YRDC, COLGALT1, IPO4, TBL1XR1, VPS37B, SLC25A22, SHCBP1, SLTM, AGMAT, NAA40, NHEJ1, CPSF7, UBA5, ZC3H14, LPCAT1, PYROXD1, ACTR5, DENND2D, NAA25, CALD1, FBXL18, ZNF606, CALM1, PTGES2, THOC7, NAA15, BRD3, NUP214, RUFY1, WDR26, C16orf70, STAM, MED28, FLAD1, CPEB4, CCDC68, PUS1, DNAJC5, WDR82, WDR61, PDHX, CALM2, UBXN6, PRR3, THUMPD2, TMEM177, CYB5B, USP5, CALM3, ZFP91, KMT2D, SETD7, YEATS4, IFT88, TUBB1, SLC25A32, CLPTM1L, PABPN1, CALR, ACTN4, CALU, SLC7A5, TAF15, PTDSS2, HM13, CAMK2A, TMX1, RCC1L, TXNDC5, PDRG1, URM1, FIP1L1, ANP32E, COIL, CDT1, TRMT1L, PPP1R14C, SF3A2, TRIM56, TMEM14B, SFXN3, ARPC5L, RAB1B, LAS1L, SLIRP, DPF1, CHAF1B, CANX, USP11, USP9X, KDM5C, SMC1A, NAA10, CAPNS1, UBL4A, LAGE3, ARID1A, CAPZA1, TRRAP, PICALM, CAST, FZD1, CAPZB, ADPGK, SH3BGRL3, SF3B5, CDCA3, KATNAL2, EPPK1, NUF2, COG3, DYNLRB1, TLN2, PARP9, SH3BGRL2, TRPT1, GRWD1, USP26, KLF16, TAF3, HMCN1, SNX25, EIF2A, PIP5K1A, NACAP1, PIP4K2B, SLC25A11, MAGT1, HDHD2, TAGLN2, RAB6C, UTP15, ZNF644, KAT8, RNASEH2C, POLR1B, STX7, SETD3, USP48, TMEM126A, MRI1, MED10, POLDIP3, STK24, GINS4, CHCHD6, PYM1, MRPL45, VPS25, THOC3, SARNP, C16orf13, COG8, NIFK, HOOK3, CYSTM1, DHX16, CUL4B, CUL4A, CUL1, MRPL43, TTF2, TUBB6, GLYR1, DPY30, MYPN, SMARCA5, TRIM55, PSRC1, CAT, OGT, UNC119B, TUBA1C, RAE1, TXNDC17, HPDL, PHF5A, MINA, RPUSD4, UTP4, ZFYVE19, WDR73, LTV1, FBXL20, RANBP3, ARHGAP19, UBL7, PEX3, IKBKG, IKBKAP, HAT1, YBX3, COPS3, STRIP1, API5, AGPS, ZCRB1, PIR, UNK, TNKS1BP1, ZNF518B, AP3B1, PRPF18, DENR, THOC5, YARS, KHSRP, CAV1, NOP14, SLC25A12, RUVBL1, PLPP1, USO1, CDK13, ACTL6A, PSMG1, RTCA, RNASET2, LAMTOR3, DYNLL1, IRS2, EIF3A, EIF3B, EIF3C, EIF3D, EIF3F, EIF3G, EIF3H, EIF3I, EIF4G3, SRSF9, CDC23, SERPINH1, PNPT1, EDF1, ACTN1, SNX4, SNX3, GPAA1, PABPC4, RAB11A, SNAP23, NAPG, NAPA, FPGT, SUCLG2, SUCLG1, SUCLA2, TRIM24, CCNK, BANF1, ACTN2, IQGAP1, SYNGAP1, KYAT1, GMPS, GGH, HDAC3, CDC123, SQSTM1, FUBP1, CDC16, ZPR1, NAE1, DDX18, EIF2B4, EIF2B3, EIF2B2, EIF2B5, EIF2S2, CPNE3, BUD31, MTMR2, PRPF4B, CPNE1, AP1S2, AP1M1, CCNB1, TIMELESS, WASF1, FUBP3, KYNU, AP3D1, H1FX, USP13, WASL, PLOD3, RPS6KA4, SELENBP1, RHOT2, LIMD1, KLC4, CCNH, KIAA2013, HIP1R, OTULIN, BAZ1B, SAMD1, UBA3, UBE2M, MCFD2, CCNT1, SPAG9, ZNF622, BTAF1, RPL14, GADD45GIP1, AIP, YIF1B, GPRC5A, MCU, PRC1, LRSAM1, ASH2L, PYGO2, CCT6A, ZNF598, SART1, CD1A, DNAJA3, USP14, USP10, USP8, NMI, MTA1, SLC25A46, ATP6V0D1, PDLIM1, CNOT9, SMC3, PRPF4, PRPF3, FAM50A, AIFM1, CCNB2, RABEP1, RRP9, BTF3L4, RCCD1, HGS, NEMF, ZNF830, COX7A2L, TMSB10, ELMSAN1, ZW10, BUB3, DDX21, ZBED1, FDXACB1, NDUFAF2, COG7, ZMYM3, LRRFIP1, ZC3HAV1L, INTS4, MTDH, VAPB, VAPA, MTA2, NOLC1, MRPS36, ZNF585B, RAB11B, NAF1, MRRF, LDHAL6B, AIMP1, PDLIM7, TIMM50, SLC38A5, COPB2, MED14, HNRNPLL, SRSF11, ATP6V1F, NAPRT, RPS10P5, PTER, COPS2, TRIP13, TRIP12, GTF3C5, GTF3C4, GTF3C3, MMGT1, VAMP3, EFTUD2, RPL23, SLC9A3R2, TXNL1, LONP1, TBCK, TJAP1, RAB9A, SLC9A3R1, PPT2, TM9SF2, COX5A, GRHPR, COG1, CIAO1, ACTR8, RECQL5, PIGS, MUC16, SYAP1, ZRANB2, SFXN1, SNRNP40, MED21, TJP2, DDX23, H2AFV, MED23, MED17, MED27, MED7, QKI, GSTO1, KIF23, SCARB2, PMPCB, NPEPPS, EEF1E1, TECR, VPS4B, GOSR1, BAG3, POLR1C, TP53I3, ATP6V1G1, ATP5J2, SEC22B, H2AFY, VPS26A, PREPL, RBM39, MAD2L1BP, PRDX6, WTAP, PDIA4, CD44, NCOR1, NUP155, SEC24C, ISG15, ZNF592, CTR9, GCC2, TTC37, CEP135, SAFB2, EIF5B, IPO13, SLC25A44, PPIP5K1, CLINT1, NUP93, BZW1, UBE3C, PUM1, DHX34, VPRBP, SART3, KNTC1, USP34, SETD1A, LAPTM4A, SLK, CD81, MLEC, ZFYVE16, KIAA0101, EIF4A3, TM9SF4, PIEZO1, MATR3, CDA, DHX38, DLGAP5, SPCS2, IST1, MRPL19, TOMM20, GIT2, NUP58, CUL7, CDK1, GINS1, CDK11B, C2CD5, PSMD6, MED24, TOMM70, SEC24D, TLK1, ZC3H11A, TOX4, DDX46, CDC5L, SNAP91, SEPT7, TELO2, KIAA0196, UBAP2L, RBM19, NCAPD2, RBM8A, XYLB, OXSR1, CRYZL1, WDR1, USP15, USP3, MVP, CDC27, THRAP3, MED12, MED13, NUP153, CDC42, THOC1, HNRNPDL, PTBP3, SCO2
Sample name | Organism | Experiment title | Sample type | Library instrument | Attributes | |||||||||||||||||||||||||||||||||||||||||||||||||
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