| Type | Description |
|---|---|
| Definition | ubiquitin conjugating enzyme E2 D2 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-13 10:32:00 | Ube2D2 was validated as a functional E2 enzyme for the ubiquitylation of the p53 transactivation domain (p53-TAD) by MUL1-RING, and purification and crystallization processes for MUL1-RING and the MUL1-RING-Ube2D2 complex are reported. | 31929179 |
| 2019-05-04 12:59:00 | results disclose the mechanism by which cIAP1 RING dimer activates UbcH5B approximately Ub and indicate that noncovalent Ubiquitin (Ub) binding further stabilizes the cIAP1-UbcH5B approximately Ubiquitin (Ub) complex in the active conformation to stimulate Ub transfer | 30523153 |
| 2017-07-01 11:37:00 | These results point to an important role of the affinity between RNF4 and its cognate RAD6B or UBCH5B in governing the multiplicity of substrate ubiquitination. | 27678051 |
| 2016-12-24 10:48:00 | Knockdown of UBE2D2 caused an increase in p53 protein levels, and knockdown of p53 attenuated not only cadmium-induced apoptosis, but also cadmium-induced apoptosis-related gene expression. | 26912277 |
| 2016-04-23 11:33:00 | mutations having marked effects on function only minimally affect the intermolecular interactions between the AO7 RING and UbcH5B, establishing a high degree of complexity in activation through the RING-E2 interface. | 26475854 |
| Type | IDs |
|---|---|
| Synonymous | E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B |
| Gene |
UniProtKB-ID:
UB2D2_HUMAN
UniprotKB:
P62837
UniParc:
UPI0000006BD0,
UPI000006E3BF
EMBL:
AK001428,
AK001311,
AC010378,
U39317,
AY651263,
L40146,
CH471062,
BC033349,
AF317220
Ensembl:
ENSG00000131508
KO:
hsa:7322
|
| Nucleutide sequences |
EMBL-CDS:
BAG50891.1,
BAG50911.1,
AAX35690.1,
EAW62095.1,
EAW62096.1,
AAK93958.1,
EAW62097.1,
AAC41750.1,
AAA91460.1,
AAH33349.1
Ensembl_TRS:
ENST00000398734,
ENST00000505548,
ENST00000398733,
ENST00000511725
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000381718,
ENSP00000424941,
ENSP00000381717,
ENSP00000429613
RefSeq:
NP_003330.1,
NP_862821.1,
XP_016865309.1
|
| Others |
UniRef100:
UniRef100_P62837
UniRef90:
UniRef90_P62837
UniRef50:
UniRef50_P62837
UniGene:
Hs.108332
CCDS:
CCDS43369.1,
CCDS47275.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员