| Type | Description |
|---|---|
| Definition | major vault protein |
| Date | Results | Publications |
|---|---|---|
| 2020-06-27 12:15:00 | This is the first report showing that high bone marrow LRP expression predicts significant favorable therapeutic outcome. Peripheral blood LRP expression as well as marrow and blood MDR1 and MRP2 expression have no predictive value in AML patients treated with standard dose cytarabine and daunorubicin 3+7 regimen. | 30674943 |
| 2019-10-12 11:52:00 | This study provides evidence that Notch1 activates AKT pathway and promotes EMT partly through direct activation of MVP. | 30336197 |
| 2019-09-07 12:29:00 | Study found that MVP expression was significantly up-regulated in non-small cell lung cancer (NSCLC) tissues. Higher MVP expression was correlated with better clinical outcomes in patients with lung cancer. Further findings demonstrate that MVP may act as a lung tumor suppressor via inhibiting pathway. | 31092229 |
| 2019-07-27 13:00:00 | Study shows that adipocytes induce major vault protein (MVP)-related multidrug-resistant phenotype in breast cancer cells, which could contribute to obesity-related chemoresistance. In a series of human breast tumors, a gradient of MVP expression was observed, and it was higher at the invasive front, where tumor cells are at close proximity to adipocytes, highlighting the clinical relevance of these results. | 30654824 |
| 2019-05-25 11:04:00 | Study identified major vault protein (MVP) as a suppressor for NF-kappaB signaling in macrophages. Up-regulation of MVP expression in macrophages of visceral adipose tissues was correlated with obesity in both humans and mice, suggesting that MVP be involved in obesity-associated inflammation.Results demonstrate that macrophage MVP constitutes a key constraint of NF-kappaB signaling thereby suppressing metabolic diseases. | 30996248 |
| Type | IDs |
|---|---|
| Synonymous | LRP, VAULT1 |
| Gene |
UniProtKB-ID:
MVP_HUMAN,
X5D7K9_HUMAN,
X5D2M8_HUMAN,
X5DNU0_HUMAN
UniprotKB:
Q14764,
X5D7K9,
X5D2M8,
X5DNU0
UniParc:
UPI000012FA9C,
UPI0004436DA8,
UPI0004436B93
EMBL:
AJ238519,
AJ238514,
AJ291367,
AJ238516,
AJ291365,
AJ291366,
CH471238,
KJ534884,
X79882,
BC015623,
KJ534885,
AJ238512,
KJ534886,
AJ238518,
HM005570
Ensembl:
ENSG00000013364
KO:
hsa:9961
|
| Nucleutide sequences |
EMBL-CDS:
CAB55354.1,
CAA56256.2,
AAH15623.1,
CAC35316.1,
CAC35314.1,
CAC35313.1,
CAB55355.1,
AHW56525.1,
EAW79983.1,
EAW79982.1,
EAW79981.1,
AEE61167.1,
EAW79984.1,
AHW56524.1,
AHW56526.1
Gene_ORFName:
hCG_1985644
Ensembl_TRS:
ENST00000357402,
ENST00000395353
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000349977,
ENSP00000378760
RefSeq:
NP_001280134.1,
NP_059447.2,
NP_001280133.1,
NP_005106.2
|
| Others |
UniRef100:
UniRef100_X5D7K9,
UniRef100_Q14764,
UniRef100_X5DNU0
UniRef90:
UniRef90_X5D7K9,
UniRef90_A0A2K5D4K8,
UniRef90_Q14764
UniRef50:
UniRef50_A0A2K5D4K8,
UniRef50_H9GLK9,
UniRef50_Q14764
UniGene:
Hs.632177
CCDS:
CCDS10656.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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