| Type | Description |
|---|---|
| Definition | THO complex 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:36:00 | Knockdown of THOC1 reduces the proliferation of hepatocellular carcinoma and increases the sensitivity to cisplatin. | 32669125 |
| 2020-09-26 13:09:00 | THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis. | 32776944 |
| 2017-12-16 12:24:00 | THO interacts with the Sin3A histone deacetylase complex to suppress co-transcriptional R-loops, DNA damage, and replication impairment. Functional analyses show that histone hypo-acetylation prevents accumulation of harmful R-loops and RNA-mediated genomic instability. | 29074626 |
| 2016-03-26 10:31:00 | Colorectal cancer patients with high levels of Thoc1 expression had poorer overall-survival and disease-free survival, whereas those with lower levels of Thoc1 expression survived longer. | 26545775 |
| 2015-01-31 11:51:00 | In humans, high THOC1 protein expression associates with prostate cancer aggressiveness and recurrence. Thus, THOC1 protein is a molecular marker that may improve the identification of aggressive prostate cancers, potentially reducing overtreatment. | 25296641 |
| Type | IDs |
|---|---|
| Synonymous | HPR1, P84, P84N5 |
| Gene |
UniProtKB-ID:
THOC1_HUMAN
UniprotKB:
Q96FV9
UniParc:
UPI0000441ECA,
UPI0000071782
EMBL:
AY573302,
CH471113,
AK314755,
AP000845,
BC010381,
L36529,
AY573303
Ensembl:
ENSG00000079134
KO:
hsa:9984
|
| Nucleutide sequences |
EMBL-CDS:
AAT81409.1,
AAA53571.1,
AAH10381.1,
BAG37293.1,
EAX01732.1,
AAT81408.1
Ensembl_TRS:
ENST00000261600
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000261600
RefSeq:
XP_011524076.1,
XP_016881593.1,
XP_011524075.1,
XP_011524074.1,
NP_005122.2,
XP_024307060.1
|
| Others |
UniRef100:
UniRef100_Q96FV9
UniRef90:
UniRef90_Q96FV9
UniRef50:
UniRef50_Q96FV9
UniGene:
Hs.712543
CCDS:
CCDS45820.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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