| Type | Description |
|---|---|
| Definition | replication timing regulatory factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:33:00 | The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress. | 33141022 |
| 2020-03-21 12:05:00 | we identified RIF1 as the critical effector of 53BP1. Inhibiting 53BP1 recruitment to damaged chromatin completely abolished the survival advantage after multifractionated irradiation and could not be reversed by suppressing excessive end resection. | 31822909 |
| 2020-02-29 11:09:00 | 53BP1 and RIF1 assemble a higher-order structure in the vicinity of damaged chromatin to protect it from unscheduled DNA-end resection. | 31792447 |
| 2019-09-07 12:32:00 | the differential H4K20 methylation status between pre-replicative and post-replicative DNA represents an intrinsic mechanism that locally ensures appropriate recruitment of the 53BP1-RIF1-MAD2L2 complex at DNA double strand breaks. | 29160738 |
| 2019-07-20 12:40:00 | Study reported that RIF1 is SUMOlyated in response to DNA damage and identified PIAS4 as the primary SUMO E3 ligase required for the SUMOylation of RIF1 protein. Mammalian cells compromised of PIAS4 expression, show impaired RIF1 SUMOylation and defective for the disassembly of DNA damage responsive RIF1 foci. | 29234018 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
RIF1_HUMAN
UniprotKB:
Q5UIP0
UniParc:
UPI000023729F,
UPI000053E94D
EMBL:
AC009311,
U79263,
AL080129,
AY727910,
AK024033,
AY727912,
AK074349,
AY584066,
AY727913,
AK001461,
AK022932,
CR933663,
AC009497,
AY585745,
AY727911
Ensembl:
ENSG00000080345
KO:
hsa:55183
|
| Nucleutide sequences |
EMBL-CDS:
AAT40745.1,
BAB14792.1,
BAB14313.1,
CAI45961.1,
AAV51402.1,
AAB50209.1,
AAV51403.1,
AAS94233.1,
BAB85058.1,
AAV51404.1,
AAV51401.1,
CAB45727.1,
BAA91705.1
Ensembl_TRS:
ENST00000428287,
ENST00000243326,
ENST00000453091,
ENST00000430328,
ENST00000444746
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000390181,
ENSP00000414615,
ENSP00000415691,
ENSP00000416123,
ENSP00000243326
RefSeq:
XP_011509697.1,
XP_024308740.1,
NP_001171136.1,
NP_060621.3,
XP_016859914.1,
XP_016859911.1,
XP_016859912.1,
XP_005246722.1,
NP_001171135.1,
XP_016859913.1,
NP_001171134.1
|
| Others |
UniRef100:
UniRef100_Q5UIP0
UniRef90:
UniRef90_Q5UIP0
UniRef50:
UniRef50_Q5UIP0
UniGene:
Hs.655671,
Hs.735592
CCDS:
CCDS54406.1,
CCDS2194.1
|
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|---|---|---|---|---|---|---|---|---|
| Refseq |
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