| Type | Description |
|---|---|
| Definition | phosphoglycerate mutase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 10:51:00 | The aim of this review is to update scientific research network with cancer-specific role of PGAM1 to elucidate its capability as bonafide therapeutic target for cancer therapy. | 31169978 |
| 2019-09-21 10:06:00 | PGAM1 is thus a downstream effector of mTOR signaling pathway and mTOR-PGAM1 signaling cascade may contribute to the development of Warburg effect observed in cancer. | 29362480 |
| 2019-05-18 10:12:00 | Knockdown of PGAM1 by siRNA in PC-3 and 22Rv1 prostate cancer cell lines inhibited cell proliferation, migration, and invasion and enhanced cancer cell apoptosis. In a nude mouse xenograft model, PGAM1 knockdown markedly suppressed tumor growth. Deletion of PGAM1 resulted in decreased expression of Bcl-2, enhanced expression of Bax, caspases-3 and inhibition of MMP-2 and MMP-9 expression. | 29271400 |
| 2018-11-10 12:20:00 | High PGAM1 expression is associated with Pancreatic Ductal Adenocarcinoma Metastasis. | 29386088 |
| 2018-07-28 10:10:00 | conformation and dynamics of the C-terminal region in human phosphoglycerate mutase 1 | 28748916 |
| Type | IDs |
|---|---|
| Synonymous | HEL-S-35, PGAM-B, PGAMA |
| Gene |
UniProtKB-ID:
PGAM1_HUMAN,
Q6FHU2_HUMAN,
B7Z9E5_HUMAN
UniprotKB:
P18669,
Q6FHU2,
B7Z9E5
UniParc:
UPI0001915416,
UPI000013E9FE
EMBL:
AK293023,
CR541659,
BC073742,
AY007118,
BC011678,
BC010038,
CH471054,
AK312351,
BC157873,
AK292216,
CH471066,
BC066959,
J04173,
EU794644,
BC053356,
AK315910
Ensembl:
ENSG00000171314
KO:
hsa:5223
|
| Nucleutide sequences |
EMBL-CDS:
AAH10038.1,
AAH53356.1,
AAH66959.1,
AAH11678.1,
AAH73742.1,
AAA60071.1,
AAG01990.1,
EAW97735.1,
BAF85712.1,
BAG35272.1,
EAW97732.1,
EAW49938.1,
CAG46460.1,
AAI57874.1,
ACJ13698.1,
BAF84905.1,
EAW49944.1,
EAW49939.1,
BAH14281.1
Gene_ORFName:
CDABP0006,
hCG_25778,
hCG_2015269
Ensembl_TRS:
ENST00000334828
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000359991
RefSeq:
NP_002620.1,
NP_001304008.1
|
| Others |
UniRef100:
UniRef100_P18669,
UniRef100_B7Z9E5
UniRef90:
UniRef90_B7Z9E5,
UniRef90_P18669
UniRef50:
UniRef50_A0A0S7KZ82,
UniRef50_P18669
UniGene:
Hs.632918
CCDS:
CCDS7458.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员