| Type | Description |
|---|---|
| Definition | ribosomal L1 domain containing 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-06-23 00:09:00 | CSIG enhanced the phosphatase activity of PPM1A and further inhibited TGF-beta signaling. | 30201805 |
| 2018-05-05 10:50:00 | The nucleolar protein CSIG is a novel and crucial regulator of the MDM2-p53 pathway. We demonstrate that CSIG translocates from the nucleolus to the nucleoplasm in response to nucleolar stress. Moreover, knockdown of CSIG attenuates the induction of p53 and abrogates G1 phase arrest in response to nucleolar stress | 27811966 |
| 2016-01-16 10:09:00 | High CSIG promotes hepatocellular carcinoma proliferation by activating c-MYC expression. | 25749381 |
| 2010-01-21 00:00:00 | CSIG acts as a novel regulatory component of replicative senescence, which requires PTEN as a mediator and involves in a translational regulatory mechanism. | 18678645 |
| 2010-01-21 00:00:00 | Our results suggest that PBK1 is involved in the regulation of uPA expression, which might provide a new clue to further understanding the regulation mechanism of uPA expression. | 15880258 |
| Type | IDs |
|---|---|
| Synonymous | CSIG, L12, PBK1, UTP30 |
| Gene |
UniProtKB-ID:
RL1D1_HUMAN
UniprotKB:
O76021
UniParc:
UPI00017A7119,
UPI000007374D
EMBL:
CH471112,
BC019069,
AY154473,
AF083127,
BC113699,
BC112228,
AY598331,
AJ007398,
AL049999,
AC010654,
AK295935
Ensembl:
ENSG00000171490
KO:
hsa:26156
|
| Nucleutide sequences |
EMBL-CDS:
AAT06742.1,
AAI13700.1,
AAH19069.2,
AAI12229.1,
BAG58720.1,
CAA07491.1,
EAW85133.1,
AAN46298.1,
EAW85135.1,
AAF98239.1,
CAB43231.2
Gene_ORFName:
L12
Ensembl_TRS:
ENST00000571133
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000460871
RefSeq:
NP_056474.2
|
| Others |
UniRef100:
UniRef100_O76021
UniRef90:
UniRef90_O76021
UniRef50:
UniRef50_O76021
UniGene:
Hs.401842
CCDS:
CCDS10551.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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