| Type | Description |
|---|---|
| Definition | protein phosphatase 1 catalytic subunit gamma |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:20:00 | Aurora B regulates PP1gamma-Repo-Man interactions to maintain the chromosome condensation state. | 32938714 |
| 2020-05-09 12:09:00 | our work has identified both the mechanism of SLFN11 activation and PPP1CC as the enzyme responsible for its activation. Our findings open up future studies of the PPP1CC subunit(s) involved in SLFN11 activation and the putative kinase(s) that inactivates SLFN11. | 31395656 |
| 2017-11-04 11:44:00 | Here the authors show how Ki-67 and RepoMan form mitotic exit phosphatases by recruiting PP1, how they distinguish between distinct PP1 isoforms and how the assembly of these two holoenzymes are dynamically regulated by Aurora B kinase during mitosis. | 27572260 |
| 2017-08-12 10:42:00 | Data suggest that PPP1CC catalyzes hydrolysis of an assortment of substrates (aryl methylphosphonates, fluorophosphate esters, phosphorothioate esters, phosphodiesters); conservative mutation of R221 to K results in a mutant that is more effective catalyst toward monoanionic substrates; PPP1CC does not catalyze the hydrolysis of a sulfate ester, which is unexpected. | 28678475 |
| 2017-07-15 12:29:00 | PP1gamma is upregulated in hepatocellular carcinoma (HCC) cell lines and HCC specimens and promotes cancer cell proliferation through regulation of p53. High expression of PP1gamma in HCC cells contributed to doxorubicin resistance. | 27921263 |
| Type | IDs |
|---|---|
| Synonymous | PP-1G, PP1C, PPP1G |
| Gene |
UniProtKB-ID:
PP1G_HUMAN,
A0A024RBP2_HUMAN
UniprotKB:
P36873,
A0A024RBP2
UniParc:
UPI000002B16F,
UPI0000111E6E
EMBL:
X74008,
L07395,
CH471054,
BC014073
Ensembl:
ENSG00000186298
KO:
hsa:5501
|
| Nucleutide sequences |
EMBL-CDS:
AAH14073.1,
AAA19823.1,
CAA52169.1,
EAW97940.1,
EAW97939.1
Gene_ORFName:
hCG_38556
Ensembl_TRS:
ENST00000335007,
ENST00000340766
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000335084,
ENSP00000341779
RefSeq:
XP_011536807.1,
NP_001231903.1,
XP_011536806.1,
NP_002701.1
|
| Others |
UniRef100:
UniRef100_P36873
UniRef90:
UniRef90_P36873
UniRef50:
UniRef50_P36873
UniGene:
Hs.79081
CCDS:
CCDS9150.1,
CCDS58279.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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