| Type | Description |
|---|---|
| Definition | hepatocyte growth factor-regulated tyrosine kinase substrate |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:15:00 | Epstein-Barr Virus LMP1 Promotes Syntenin-1- and Hrs-Induced Extracellular Vesicle Formation for Its Own Secretion To Increase and Migration. | 32546618 |
| 2020-06-20 10:54:00 | Study provides in vivo evidence that Beclin 1 suppresses tumor proliferation by regulating the endocytic trafficking and degradation of the EGFR and transferrin (TFR1) receptors. Beclin 1 promoted endosomal recruitment of hepatocyte growth factor tyrosine kinase substrate (HRS), which was necessary for sorting surface receptors to intraluminal vesicles for signal silencing and lysosomal degradation. | 31744816 |
| 2020-06-13 11:55:00 | The ESCRT-0 protein HRS interacts with the HTLV-II antisense protein APH-2 and suppresses viral replication. [APH-2] | 31597781 |
| 2019-08-03 13:06:00 | Post-traumatic stress disorder (PTSD) is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts. | 30456986 |
| 2019-07-06 10:31:00 | Degradation of CLR-RAMP2 was sensitive to overexpression of hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), but not to HRS knockdown, whereas CLRDelta9KR-RAMP2 degradation was unaffected. Overexpression, but not knockdown of HRS, promoted hyperubiquitination of CLR under basal conditions. These results propose a role for ubiquitin and HRS in the regulation of AM-induced degradation of CLR-RAMP2. | 28959041 |
| Type | IDs |
|---|---|
| Synonymous | HRS |
| Gene |
UniProtKB-ID:
HGS_HUMAN,
A0A0S2Z4R4_HUMAN
UniprotKB:
O14964,
A0A0S2Z4R4
UniParc:
UPI000004493D,
UPI0000374511
EMBL:
BT009754,
U43895,
D84064,
AF260566,
KU178466,
CH471099,
BC003565
Ensembl:
ENSG00000185359
KO:
hsa:9146
|
| Nucleutide sequences |
EMBL-CDS:
AAP88756.1,
BAA23366.1,
AAF82361.1,
AAH03565.1,
AAC51929.1,
ALQ33924.1,
EAW89675.1
Gene_ORFName:
hCG_1987560
Ensembl_TRS:
ENST00000329138
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000331201
RefSeq:
NP_004703.1
|
| Others |
UniRef100:
UniRef100_O14964
UniRef90:
UniRef90_O14964
UniRef50:
UniRef50_O14964
UniGene:
Hs.661056
CCDS:
CCDS11784.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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