| Type | Description |
|---|---|
| Definition | N(alpha)-acetyltransferase 40, NatD catalytic subunit |
| Date | Results | Publications |
|---|---|---|
| 2020-05-23 12:09:00 | The findings strengthen the importance of NAA40 to maintain colorectal cancer cell growth. We show that NAA40 oncogenic properties stimulate the global levels of H4R3me2s by transcriptionally activating PRMT5 methyltransferase which in turn modulates the expression of key downstream cancer-related genes. | 30858358 |
| 2018-02-10 11:47:00 | NatD-mediated acetylation of histone H4 serine 1 competes with phosphorylation by CK2alpha at the same residue, leading to the upregulation of Slug and lung cancer progression. | 29030587 |
| 2016-10-22 12:17:00 | findings reveal an anti-apoptotic role for Naa40 and exhibit its potential as a therapeutic target in colorectal cancers. | 26666750 |
| 2014-07-26 11:20:00 | The knowledge of detailed molecular architecture of Patt1 is not only the key to understanding its mechanistic functional properties but it also opens the possibility of rational drug and protein design experiments | 24248912 |
| 2012-03-03 11:15:00 | Results strongly suggest that human Naa40p/NatD is conserved from yeast. Thus, the NATs of all classes of N-terminally acetylated proteins in humans now appear to be accounted for. | 21935442 |
| Type | IDs |
|---|---|
| Synonymous | NAT11, NatD, PATT1, hNatD |
| Gene |
UniProtKB-ID:
NAA40_HUMAN,
A0A024R5C6_HUMAN
UniprotKB:
Q86UY6,
A0A024R5C6
UniParc:
UPI000019275B,
UPI00017A7C73,
UPI000041B91C
EMBL:
AK023910,
CH471076,
BC041617,
BC052298,
AK299041,
AP003780,
BX647309,
AK300451
Ensembl:
ENSG00000110583
KO:
hsa:79829
|
| Nucleutide sequences |
EMBL-CDS:
CAI46006.1,
AAH41617.1,
BAB14720.1,
BAG62172.1,
BAG61115.1,
AAH52298.1,
EAW74183.1,
EAW74184.1
Gene_ORFName:
hCG_21375
Ensembl_TRS:
ENST00000542163,
ENST00000377793
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000442055,
ENSP00000367024
RefSeq:
XP_011543556.1,
NP_079047.2,
NP_001287729.1,
XP_006718752.1,
XP_011543557.1
|
| Others |
UniRef100:
UniRef100_Q86UY6
UniRef90:
UniRef90_Q86UY6
UniRef50:
UniRef50_Q86UY6
UniGene:
Hs.523753
CCDS:
CCDS73311.1,
CCDS8053.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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