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5557 PRIM1

5557

PRIM1

DNA primase subunit 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition DNA primase subunit 1

研究结论

Date Results Publications
2019-05-25 10:53:00 the structure of human p49at 2.2A resolution with citrate in its inactive forms, is reported. 30446220
2019-04-27 10:32:00 PRIM1 was detected preferentially at a higher level (>40-fold) in poorly differentiated tumor tissues (n = 46) compared with more highly differentiated tumors tissues (n = 10) (*p = 0.005). 30097999
2019-02-16 10:59:00 PRIM1 inactivation sensitizes cancer cells to ATR and CHK1 inhibitors via S-phase stasis and Wee1-mediated, caspase 8-dependent apoptosis. 30257222
2017-07-29 11:51:00 No mutations within PRIM1 were found in Chinese women with primary ovarian insufficiency. 27599756
2016-08-06 10:52:00 Data suggest that PRIM1-p58,C-terminal domain stays bound to initiating NTP and 3prime-overhang DNA during whole cycle of RNA primer synthesis; meanwhile, PRIM1-p49 slides along DNA template toward 5prime-end with PRIM1-p58,N-terminal domain attached. 26710848

名称对应

Type IDs
Synonymous p49
Gene
UniProtKB-ID: PRI1_HUMAN
UniprotKB: P49642
UniParc: UPI00001321AF
EMBL: BC005266, U89689, X74330
Ensembl: ENSG00000198056
KO: hsa:5557
Nucleutide sequences
EMBL-CDS: AAH05266.1, CAA52377.1, AAC51726.1
Ensembl_TRS: ENST00000338193
Protein sequencees
Ensembl_PRO: ENSP00000350491
RefSeq: NP_000937.1
Others
UniRef100: UniRef100_P49642
UniRef90: UniRef90_P49642
UniRef50: UniRef50_P49642
UniGene: Hs.534339
CCDS: CCDS44926.1

全选

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