| Type | Description |
|---|---|
| Definition | lysyl-tRNA synthetase |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 13:01:00 | Hairpin RNA-induced conformational change of a eukaryotic-specific lysyl-tRNA synthetase extension and role of adjacent anticodon-binding domain. | 32611767 |
| 2020-01-11 11:37:00 | Through whole-exome sequencing, we discovered genetic abnormalities in lysyl-tRNA synthetase (KARS). All patients harboured the variant [c.1786C>T, p.Leu596Phe] KARS isoform 1 ([c.1702C>T, p.Leu568Phe] of KARS isoform 2). These KARS pathological variants are novel, including the variant [c.1786C>T; p.Leu596Phe] (c.1702C>T; p.Leu568Phe) shared by all patients in the homozygous or compound-heterozygous state. | 30715177 |
| 2019-12-14 10:38:00 | This study adds LARS2 and KARS pathogenic variants as gene defects that may underlie deafness, ovarian failure, and leukodystrophy with mitochondrial signature. | 30737337 |
| 2019-09-14 10:53:00 | KRS in colon cancer cells remodels the microenvironment to promote metastasis, which can thus be therapeutically targeted at these bidirectional KRS-dependent communications of cancer spheroids with environmental cues. | 30188867 |
| 2019-03-09 12:37:00 | This study demonstrates that human mitochondrial AspRS, ArgRS, and LysRS, each have a specific sub-mitochondrial distribution, with ArgRS being exclusively localized in the membrane, LysRS exclusively in the soluble fraction, and AspRS being present in both. | 30006346 |
| Type | IDs |
|---|---|
| Synonymous | CMTRIB, DFNB89, KARS1, KARS2, KRS |
| Gene |
UniProtKB-ID:
SYK_HUMAN
UniprotKB:
Q15046
UniParc:
UPI000004062F,
UPI00001405CB
EMBL:
AC025287,
D31890,
CH471114,
BC004132,
AF285758,
D32053
Ensembl:
ENSG00000065427
KO:
hsa:3735
|
| Nucleutide sequences |
EMBL-CDS:
AAG30114.1,
AAH04132.1,
EAW95622.1,
BAA22084.1,
BAA06688.1,
EAW95624.1
Ensembl_TRS:
ENST00000302445,
ENST00000319410
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000325448,
ENSP00000303043
RefSeq:
NP_001123561.1,
NP_005539.1,
NP_001365077.1
|
| Others |
UniRef100:
UniRef100_Q15046
UniRef90:
UniRef90_Q15046
UniRef50:
UniRef50_Q15046
UniGene:
Hs.3100
CCDS:
CCDS10923.1,
CCDS45532.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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