| Type | Description |
|---|---|
| Definition | histocompatibility minor 13 |
| Date | Results | Publications |
|---|---|---|
| 2019-05-18 11:50:00 | Study demonstrates that SPP is highly induced in lung and breast cancers and promotes tumor progression, at least in part, by facilitating the degradation of mTOR inhibitor FKBP8. | 30348988 |
| 2018-06-02 11:19:00 | Preproinsulin signal peptide epitopes are processed by SPP and loaded for HLA-guided immune recognition via pathways that are enhanced during type 1 diabetes pathogenesis. | 29343547 |
| 2018-02-10 11:24:00 | Though far from complete, our knowledge on pathophysiological functions of SPP/SPPL proteases, in particular based on studies in mice, has been significantly increased over the last years. Based on this, inhibition of distinct SPP/SPPL proteases has been proposed as a novel therapeutic concept e.g. for the treatment of autoimmunity and viral or protozoal infections, as we will discuss in this review. | 28624439 |
| 2017-12-23 11:48:00 | The domains involved in HO-1 translocation have been identified, and it was shown that SPP-mediated HO-1 cleavage is isoform-specific (HO-1 vs HO-2) and independent of heme oxygenase activity. | 29155886 |
| 2017-10-21 12:58:00 | This study identifies that SPP affects EGFRvIII secretion profiles and thus promotes tumor progression, providing further understanding of the formation of secreted vesicles and driving role of EGFRvIII in Glioblastoma. | 28198167 |
| Type | IDs |
|---|---|
| Synonymous | H13, IMP1, IMPAS, IMPAS-1, MSTP086, PSENL3, PSL3, SPP, SPPL1 |
| Gene |
UniProtKB-ID:
HM13_HUMAN,
A0A0S2Z5V7_HUMAN,
A0A0C4DGU3_HUMAN
UniprotKB:
Q8TCT9,
A0A0S2Z5V7,
A0A0C4DGU3
UniParc:
UPI000001358E,
UPI000001358F,
UPI00003E054B,
UPI000000D7D8,
UPI000002AB27
EMBL:
AL121751,
AY169310,
AK314410,
AF483215,
AK074686,
BC008959,
AY169312,
BC062595,
AY169311,
DQ168450,
KF456879,
AF172086,
CH471077,
AJ420895,
AJ345029,
AF515663,
KU178790,
AK075283,
AL110115,
BC008938
Ensembl:
ENSG00000101294
KO:
hsa:81502
|
| Nucleutide sequences |
EMBL-CDS:
AAH08938.1,
AAO12537.1,
BAC11519.1,
AAH08959.1,
AAO12535.1,
BAC11138.1,
EAW76436.1,
CAC87790.1,
EAW76435.1,
ABA56163.1,
BAG37032.1,
CAD13132.1,
EAW76438.1,
AAQ13609.1,
AAO12536.1,
AAM22076.1,
EAW76437.1,
AAN77099.1,
AAH62595.1,
ALQ34248.1
Gene_ORFName:
MSTP086
Ensembl_TRS:
ENST00000398174,
ENST00000335574,
ENST00000340852,
ENST00000674240,
ENST00000498035,
ENST00000650367
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000381237,
ENSP00000501423,
ENSP00000343032,
ENSP00000335294,
ENSP00000497632,
ENSP00000479020
RefSeq:
NP_848696.1,
NP_110416.1,
NP_848695.1,
NP_848697.1
|
| Others |
UniRef100:
UniRef100_A0A0C4DGU3,
UniRef100_Q8TCT9
UniRef90:
UniRef90_Q8TCT9,
UniRef90_Q9D8V0-2
UniRef50:
UniRef50_Q9D8V0-2,
UniRef50_Q8TCT9
UniGene:
Hs.373741
CCDS:
CCDS42861.1,
CCDS13183.1,
CCDS13182.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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