| Type | Description |
|---|---|
| Definition | 3-hydroxy-3-methylglutaryl-CoA synthase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-09-26 13:09:00 | The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer. | 32692762 |
| 2019-06-08 11:06:00 | Study showed that 5'isomiRNA of miR-140-3p (miR-140-3p-1) was preferentially expressed during the entire spectrum of preneoplastic progression in the MCF10A-derived triple negative breast cancer model. miR-140-3p-1 and its novel direct gene targets, HMGCR and HMGCS1, key enzymes in the cholesterol biosynthesis pathway, were deregulated in the normal-to-preneoplastic transition. | 30537987 |
| 2017-07-08 12:42:00 | Data suggest that HMGCS1 (HMG-CoA synthase 1) signals through ketogenesis/acetoacetate to promote cell proliferation and BRAF(V600E)-dependent MEK1 activation in BRAF(V600E)-positive melanoma and colon cancer cells; HMGCS1 co-localizes with HMGCL (HMG-CoA lyase) and BRAF(V600E) in cytosol of melanoma and colon cancer cells. (BRAF = proto-oncogene protein B-raf) | 28468827 |
| 2010-05-10 11:38:00 | The authors report high-resolution crystal structures of the human cytosolic (hHMGCS1) and mitochondrial (hHMGCS2) isoforms in binary product complexes. | 20346956 |
| 2010-01-21 00:00:00 | ACBP is a transcriptional regulator of the HMGCS1 and HMGCR genes encoding rate-limiting enzymes of cholesterol synthesis pathway. | 19088433 |
| Type | IDs |
|---|---|
| Synonymous | HMGCS |
| Gene |
UniProtKB-ID:
HMCS1_HUMAN,
A0A024R059_HUMAN
UniprotKB:
Q01581,
A0A024R059
UniParc:
UPI000012C9BC
EMBL:
X66435,
BT007302,
BC000297,
L25798,
CH471119,
AK315593
Ensembl:
ENSG00000112972
KO:
hsa:3157
|
| Nucleutide sequences |
EMBL-CDS:
AAH00297.2,
AAP35966.1,
CAA47061.1,
AAA62411.1,
EAW56054.1,
BAG37965.1,
EAW56056.1
Gene_ORFName:
hCG_36936
Ensembl_TRS:
ENST00000433297,
ENST00000325110
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000322706,
ENSP00000399402
RefSeq:
XP_024301806.1,
NP_001311152.1,
NP_001317592.1,
XP_011512338.1,
NP_001311151.1,
NP_001311148.1,
NP_001351117.1,
NP_001311153.1,
NP_001091742.1,
NP_002121.4,
NP_001311149.1
|
| Others |
UniRef100:
UniRef100_Q01581
UniRef90:
UniRef90_Q01581
UniRef50:
UniRef50_Q01581
UniGene:
Hs.397729,
Hs.741287
CCDS:
CCDS34154.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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