| Type | Description |
|---|---|
| Definition | ChaC cation transport regulator homolog 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-09-19 16:30:00 | Structural and Functional Analyses of Human ChaC2 in Glutathione Metabolism. | 31878259 |
| 2018-07-07 12:12:00 | The data revealed that CHAC2 prevented CHAC1-mediated GSH degradation, which suggests that CHAC2 competes with CHAC1 to maintain GSH homeostasis. | 29054545 |
| 2018-06-09 11:29:00 | Results showed for the first time that CHAC2 was degraded by the ubiquitin-proteasome pathway and CHAC2 expression inhibited tumor cell growth, proliferation, migration in vitro and in vivo. Mechanistic study showed that CHAC2 induced mitochondrial apoptosis and autophagy through unfolded protein response. | 28837156 |
| 2017-06-03 11:38:00 | Human and mouse ChaC2 proteins purified in vitro show 10-20-fold lower catalytic efficiency than ChaC1, although they showed comparable Km values | 27913623 |
| Type | IDs |
|---|---|
| Synonymous | GCG1 |
| Gene |
UniProtKB-ID:
CHAC2_HUMAN
UniprotKB:
Q8WUX2
UniParc:
UPI000003616C
EMBL:
BC017941,
AC007883,
BC019239,
BC053896,
CH471053,
BC025376
Ensembl:
ENSG00000143942
KO:
hsa:494143
|
| Nucleutide sequences |
EMBL-CDS:
EAX00172.1,
AAY24351.1,
AAH53896.1,
AAH19239.1,
AAH17941.1,
AAH25376.1
Ensembl_TRS:
ENST00000295304
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000295304
RefSeq:
NP_001333056.1,
NP_001008708.1
|
| Others |
UniRef100:
UniRef100_Q8WUX2
UniRef90:
UniRef90_Q8WUX2
UniRef50:
UniRef50_Q8WUX2
UniGene:
Hs.585944
CCDS:
CCDS33196.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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