| Type | Description |
|---|---|
| Definition | protein phosphatase 5 catalytic subunit |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:28:00 | Over-expression of human PP5 gene in mice induces corneal hyperplasia and leads to ocular surface squamous neoplasia. | 32703456 |
| 2020-03-14 11:18:00 | These data demonstrate that LB-100 is a catalytic inhibitor of both PP2AC and PPP5C and suggest that the observed antitumor activity might be due to an additive effect achieved by suppressing both PP2A and PPP5C. | 30679389 |
| 2020-01-25 14:08:00 | The role of the catalytic Mn(2+) ions in regulating the binding of PP5 with its substrate was investigated through MD simulations. Results reveal that the different states of Mn(2+) ions can alter the structure of the active site and the conformations of the residues coordinating the Mn(2+) ions or the substrate. | 30826056 |
| 2018-12-22 11:22:00 | This work offers insights of how cantharidin-like inhibitors interact with human PP5, potentially allowing the design of more specific and even less cytotoxic drugs for cancer treatments. | 30280322 |
| 2018-12-22 10:28:00 | PP5 binds and dephosphorylates the elastic N2B-unique sequence (N2Bus) of titin in cardiomyocytes. PP5 is pathologically elevated and likely contributes to hypo-phosphorylation of N2Bus in failing human hearts. Furthermore, Hsp90-activated PP5 interacts with components of a sarcomeric, N2Bus-associated, mechanosensor complex, and blocks mitogen-activated protein-kinase signaling in this complex. | 29343782 |
| Type | IDs |
|---|---|
| Synonymous | PP5, PPP5, PPT |
| Gene |
UniProtKB-ID:
PPP5_HUMAN,
A0A024R0Q7_HUMAN
UniprotKB:
P53041,
A0A024R0Q7
UniParc:
UPI0000041859
EMBL:
BC001970,
U25174,
BT007275,
X89416,
AC007193,
CH471126,
X92121
Ensembl:
ENSG00000011485
KO:
hsa:5536
|
| Nucleutide sequences |
EMBL-CDS:
AAB60384.1,
AAP35939.1,
AAD22669.1,
AAH01970.1,
CAA61595.1,
EAW57416.1,
CAA63089.1,
EAW57417.1
Gene_ORFName:
hCG_21093
Ensembl_TRS:
ENST00000012443
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000012443
RefSeq:
NP_006238.1,
NP_001191213.1,
XP_016882424.1
|
| Others |
UniRef100:
UniRef100_P53041
UniRef90:
UniRef90_P53041
UniRef50:
UniRef50_P53041
UniGene:
Hs.654604
CCDS:
CCDS12684.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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