| Type | Description |
|---|---|
| Definition | adaptor related protein complex 2 subunit alpha 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-10-27 10:45:00 | Results revealed thirteen novel splice junctions of previously annotated exons. Consecutive nested PCRs led to the determination of the primary structure of seventy-seven novel AP2A1 transcripts, all of which were shown to comprise at least one premature translation termination codon, thus representing nonsense-mediated mRNA decay candidates. | 30081190 |
| 2017-07-22 11:48:00 | AP-2alpha depletion enhanced apoptosis, demonstrating that disrupting the HIV-1 Nef:AP-2alpha interaction limits Nef-mediated apoptosis. | 28577469 |
| 2016-02-13 12:19:00 | These results lead to a model for the docking of the full AP-2 tetramer to membranes as bound to Nef, such that the cytosolic tail of CD4 is situated to interact with its binding site on Nef. | 24473078 |
| 2012-04-26 16:08:00 | A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. | 22360420 |
| 2010-01-21 00:00:00 | nef usurps AP-2 complexes to dysregulate Ii (invariant chain (Ii)/major histocompatibility complex class II) trafficking and potentially interfere with antigen presentation in the context of MHC-II | 18524831 |
| Type | IDs |
|---|---|
| Synonymous | ADTAA, AP2-ALPHA, CLAPA1 |
| Gene |
UniProtKB-ID:
AP2A1_HUMAN
UniprotKB:
O95782
UniParc:
UPI0000167B50,
UPI0000037C08
EMBL:
AF289221,
BC014214,
AC011495,
AC006942,
AC098783,
AL136925
Ensembl:
ENSG00000196961
KO:
hsa:160
|
| Nucleutide sequences |
EMBL-CDS:
CAB66859.1,
AAL11039.1,
AAD15564.1,
AAH14214.1,
AAL11040.1
Ensembl_TRS:
ENST00000359032,
ENST00000354293
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000351926,
ENSP00000346246
RefSeq:
XP_011524858.1,
NP_055018.2,
NP_570603.2,
XP_011524859.1
|
| Others |
UniRef100:
UniRef100_O95782
UniRef90:
UniRef90_O95782
UniRef50:
UniRef50_O95782
UniGene:
Hs.467125
CCDS:
CCDS46149.1,
CCDS46148.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员