| Type | Description |
|---|---|
| Definition | eukaryotic translation initiation factor 2 alpha kinase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:34:00 | EIF2AK2 Missense Variants Associated with Early Onset Generalized Dystonia. | 33236446 |
| 2021-02-20 13:33:00 | Hepatitis C virus exploits cyclophilin A to evade PKR. | 32539931 |
| 2021-01-09 13:25:00 | Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells. | 31554935 |
| 2020-09-19 10:34:00 | The demonstrate the clear involvement of protein kinase R (PKR) in abnormal spatial memory and brain lesions in the 5xFAD model and underline its interest as a target for neuroprotection in Alzheimer's disease. | 30821420 |
| 2020-08-22 15:27:00 | PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing. | 31772125 |
| Type | IDs |
|---|---|
| Synonymous | EIF2AK1, PKR, PPP1R83, PRKR |
| Gene |
UniProtKB-ID:
E2AK2_HUMAN,
Q8IW76_HUMAN
UniprotKB:
P19525,
Q8IW76
UniParc:
UPI000000D925,
UPI0000366EEE,
UPI0000074542
EMBL:
AF167468,
AF167462,
M85294,
U50637,
AF167470,
U50642,
U50644,
BC101475,
BC093676,
AK290655,
AK313818,
AY302136,
AF167466,
AF167472,
U50645,
AF167464,
U50638,
AF167465,
AF167463,
U50643,
BC057805,
AY228338,
U50646,
U50647,
CH471053,
U50635,
BC040851,
U50641,
AF167460,
M35663,
U50640,
U50636,
U50639,
U50634,
AC007899,
U50648
Ensembl:
ENSG00000055332
KO:
hsa:5610
|
| Nucleutide sequences |
EMBL-CDS:
AAA18253.1,
BAG36554.1,
EAX00408.1,
AAI01476.1,
AAA36409.1,
AAP57628.1,
AAY24317.1,
AAF13156.1,
AAO38055.1,
EAX00407.1,
AAC50768.1,
EAX00409.1,
AAH93676.1,
BAF83344.1,
AAH57805.1,
AAH40851.1
Ensembl_TRS:
ENST00000395127,
ENST00000233057,
ENST00000647926,
ENST00000405334
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000378559,
ENSP00000385014,
ENSP00000233057,
ENSP00000497534
RefSeq:
NP_002750.1,
NP_001129124.1,
XP_011531289.1,
XP_016859992.1,
NP_001129123.1
|
| Others |
UniRef100:
UniRef100_Q8IW76,
UniRef100_P19525
UniRef90:
UniRef90_P19525
UniRef50:
UniRef50_P19525
UniGene:
Hs.131431
CCDS:
CCDS46259.1,
CCDS1786.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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