| Type | Description |
|---|---|
| Definition | acylaminoacyl-peptide hydrolase |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 12:14:00 | APEH knockdown abrogated RAS-RAF-MAPK signaling in cells expressing the constitutively active (oncogenic) mutant of KRAS (KRASG12V), and selectively inhibited the proliferation of KRAS-transformed pancreatic cancer cells. Taken together, these results identify APEH as a novel drug target for a potential anti-KRAS therapeutic. | 31266814 |
| 2017-10-14 11:36:00 | Although APEH is primarily localized in the cytoplasm, a sub-fraction of this enzyme is sequestered at sites of nuclear damage following UVA irradiation or following oxidative stress. APEH interacts with the amino-terminal domain of XRCC1, and APEH facilitates both single-strand break repair and cell survival following exposure to H2O2. Thus, APEH as a novel proteolytic component of the DNA damage response. | 28866241 |
| 2017-08-12 12:07:00 | APEH polymorphism has significant influence on valproic acid pharmacokinetics in Chinese population | 27406852 |
| 2012-03-03 11:15:00 | Studies indicate that the cylindromatosis/turban tumor syndrome gene (CYLD) ranked highest, followed by acylaminoacyl-peptidase (APEH), dystroglycan (DAG1), macrophage-stimulating protein (MST1) and ubiquitin-specific peptidase 4 (USP4). | 21931648 |
| 2010-09-15 22:06:00 | Observational study of gene-disease association. (HuGE Navigator) | 20529763 |
| Type | IDs |
|---|---|
| Synonymous | AARE, ACPH, APH, D3F15S2, D3S48E, DNF15S2, OPH |
| Gene |
UniProtKB-ID:
ACPH_HUMAN
UniprotKB:
P13798
UniParc:
UPI00000735A1
EMBL:
D38441,
BC000362,
BC001826,
AF141383,
J03068,
BC001499
Ensembl:
ENSG00000164062
KO:
hsa:327
|
| Nucleutide sequences |
EMBL-CDS:
AAH01826.1,
AAH01499.1,
BAA07476.1,
AAA35769.1,
AAF37321.1,
AAH00362.1
Ensembl_TRS:
ENST00000296456
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000296456
RefSeq:
XP_024309270.1,
XP_016861774.1,
XP_005265154.1,
XP_024309274.1,
XP_024309275.1,
XP_024309273.1,
XP_011531963.1,
XP_024309272.1,
XP_016861775.1,
XP_024309268.1,
XP_024309267.1,
XP_024309269.1,
NP_001631.3,
XP_011531960.1,
XP_024309271.1,
XP_005265155.1,
XP_011531964.1,
XP_011531965.1
|
| Others |
UniRef100:
UniRef100_P13798
UniRef90:
UniRef90_P13798
UniRef50:
UniRef50_P13798
UniGene:
Hs.517969
CCDS:
CCDS2801.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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