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3281 HSBP1

3281

HSBP1

heat shock factor binding protein 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition heat shock factor binding protein 1

研究结论

Date Results Publications
2020-04-11 12:38:00 The functional HSPB1 rs2868371 promoter variant may affect lung cancer survival by regulation of HSPB1 expression levels through glucocorticoid receptor interaction. 31015126
2019-07-27 10:26:00 the armadillo-type NEFs budding yeast Fes1 and its human homolog HspBP1 employ flexible N-terminal release domains (RDs) with substrate-mimicking properties to ensure the efficient release of persistent substrates from Hsp70 29323280
2019-03-09 11:11:00 Here, we identify the small coiled-coil protein HSBP1 as a factor that specifically promotes the assembly of a ternary complex composed of CCDC53, WASH, and FAM21 by dissociating the CCDC53 homotrimeric precursor. HSBP1 operates at the centrosome, which concentrates the building blocks. 29844016
2018-07-21 11:36:00 HSPB1 protects cells against proapoptotic agents when expressed at high level, while inhibition of its expression has been found to predispose cells to apoptosis. 28828227
2018-03-24 11:11:00 Results presented here show that acquisition of a positive charge in HSBP1, either by protonation of His124 or its substitution by lysine, reduces the stability of the dimer interface of the alpha-crystallin domain, increases oligomeric size, and modestly increases chaperone activity. 28332148

名称对应

Type IDs
Synonymous NPC-A-13
Gene
UniProtKB-ID: HSBP1_HUMAN
UniprotKB: O75506
UniParc: UPI000004B12F
EMBL: AF068754, BX537440, AY320409, BC007515
Ensembl: ENSG00000230989
KO: hsa:3281
Nucleutide sequences
EMBL-CDS: AAC25186.1, AAH07515.1, AAP73809.1, CAD97682.1
Ensembl_TRS: ENST00000433866, ENST00000570259
Protein sequencees
Ensembl_PRO: ENSP00000392896, ENSP00000458007
RefSeq: NP_001528.1
Others
UniRef100: UniRef100_O75506
UniRef90: UniRef90_O75506
UniRef50: UniRef50_O75506
UniGene: Hs.250899
CCDS: CCDS45534.1

全选

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研究热度

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