| Type | Description |
|---|---|
| Definition | sorbitol dehydrogenase |
| Date | Results | Publications |
|---|---|---|
| 2020-02-08 10:45:00 | ALR2 rs759853 and SDH rs2055858 polymorphisms were respectively associated with a higher and lower risk of diabetic retinopathy. | 31539366 |
| 2017-06-03 10:08:00 | SDH gene expression was increased by hypoxia and oxidative stress, but not extracellular hyperosmolarity. Hyperosmolarity and hypoxia did not alter the SDH protein level. | 27628063 |
| 2015-01-10 13:41:00 | One of the most striking changes involved sorbitol dehydrogenase, a key enzyme in the polyol pathway. Validation studies revealed dramatically increased sorbitol dehydrogenase concentrations and activity in adenomas and cancer cell lines, along with important changes in the expression of other enzymes in the same (AKR1B1) and related (KHK) pathways. | 24567419 |
| 2013-12-21 10:48:00 | The SDH level was significantly decreased in patients with proliferative compared with non-proliferative retinopathy in both insulin and oral diabetic groups. | 23452182 |
| 2013-12-14 10:39:00 | Thus, our findings suggest that the -888G > C polymorphism in the SORD gene is not involved in the pathogenesis of diabtic retinopathy in type 2 diabetes. | 23850972 |
| Type | IDs |
|---|---|
| Synonymous | HEL-S-95n, SORD1 |
| Gene |
UniProtKB-ID:
DHSO_HUMAN
UniprotKB:
Q00796
UniParc:
UPI0001914B55,
UPI000013D771
EMBL:
U07361,
BC021085,
U67243,
U67237,
U67240,
AK295656,
L29253,
L29250,
U67238,
L29252,
AC090888,
L29249,
AC091117,
U67239,
L29254,
BC025295,
L29008,
AK312444,
U67241,
U67242,
U67236,
L29251
Ensembl:
ENSG00000140263
KO:
hsa:6652
|
| Nucleutide sequences |
EMBL-CDS:
BAG35352.1,
AAA80565.1,
BAH12142.1,
AAA66064.1,
AAH25295.1,
AAB61898.1,
AAA80566.1,
AAH21085.1
Ensembl_TRS:
ENST00000558789,
ENST00000267814
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000453904,
ENSP00000267814
RefSeq:
NP_003095.2
|
| Others |
UniRef100:
UniRef100_Q00796
UniRef90:
UniRef90_Q00796
UniRef50:
UniRef50_Q00796
UniGene:
Hs.878
CCDS:
CCDS10116.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员