| Type | Description |
|---|---|
| Definition | deoxyribonuclease 2, lysosomal |
| Date | Results | Publications |
|---|---|---|
| 2020-02-15 10:09:00 | Study of the copy number variations (CNVs) for DNASE1L3 and DNASE2 in Japanese and German populations found that only 2 diploid copy numbers for these DNASE CNVs was distributed in both populations; no copy loss or gain was evident for any of the autoimmune-related DNase genes. These human autoimmune-related DNase genes show low genetic diversity of CNVs resulting in alterations of the in vivo levels of DNase activity. | 31022206 |
| 2019-03-09 11:01:00 | DNase2 participate in the degradation of DNA during cornification in the interfollicular epidermis of mice.Cornification of epidermal keratinocytes depends on the cooperation of DNase1L2 and DNase2. | 28743926 |
| 2018-10-06 12:10:00 | Study identifies biallelic mutations in DNASE2, associated with a loss of DNase II endonuclease activity causing type I interferonopathy in three patients from two unrelated families. | 29259162 |
| 2017-04-01 11:36:00 | Single nucleotide polymorphisms producing a loss-of-function variant of the enzymes in DNASE1, DNASE1L3, and DNASE2, possibly serving as a genetic risk factor for autoimmune diseases, were confirmed. | 27116004 |
| 2014-07-12 12:18:00 | 15 nonsynonymous human DNase II SNPs were genotyped in three ethnic groups including 16 different populations using the PCR-restriction fragment length polymorphism technique. | 24242851 |
| Type | IDs |
|---|---|
| Synonymous | DNASE2A, DNL, DNL2 |
| Gene |
UniProtKB-ID:
DNS2A_HUMAN,
A0A024R7F4_HUMAN
UniprotKB:
O00115,
A0A024R7F4
UniParc:
UPI0001914EA6,
UPI000012988A
EMBL:
BC065209,
AK297493,
AC020934,
AF047016,
AD000092,
AF045937,
AF060222,
AB004574,
AK315358,
BT007047,
CH471106,
BC010419,
AB008564
Ensembl:
ENSG00000105612
KO:
hsa:1777
|
| Nucleutide sequences |
EMBL-CDS:
BAG37753.1,
EAW84320.1,
AAH65209.1,
AAC77366.1,
AAB51172.1,
BAB55598.1,
AAC35751.1,
BAA28623.1,
BAH12592.1,
AAH10419.3,
AAP35696.1,
AAC39852.1,
EAW84322.1
Gene_ORFName:
hCG_172486
Ensembl_TRS:
ENST00000222219
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000222219
RefSeq:
NP_001366.1
|
| Others |
UniRef100:
UniRef100_O00115
UniRef90:
UniRef90_O00115
UniRef50:
UniRef50_O00115
UniGene:
Hs.118243
CCDS:
CCDS12284.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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