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5110 PCMT1

5110

PCMT1

protein-L-isoaspartate (D-aspartate) O-methyltransferase

protein-coding

Homo sapiens

基因描述

Type Description
Definition protein-L-isoaspartate (D-aspartate) O-methyltransferase

研究结论

Date Results Publications
2021-04-13 10:09:00 PIMT Binding to C-Terminal Ala459 of CAIX Is Involved in Inside-Out Signaling Necessary for Its Catalytic Activity. 33198416
2019-07-27 11:20:00 High expression of PCMT1 is associated with pancreatic cancer. 29517839
2019-01-12 10:11:00 The new findings reported here extend the list of human PIMT variants that may contribute to neurological diseases in the young and the decline of CNS function in the aged. 29856810
2017-12-16 11:23:00 decrease of PCMT1 significantly increased the proportion of D-Asp residues in PHB1 and had significant and fatal impacts on morphology and functions of the mitochondria, such as ATP production and the mitochondrial fusion-fission system 27327778
2017-07-08 12:06:00 PIMT heterozygosity for R36C, G175R, R17H, or R17S would be detrimental to successful aging, whereas homozygosity (should it ever occur) would produce devastating neuropathology 28100787

名称对应

Type IDs
Synonymous PIMT
Gene
UniProtKB-ID: PIMT_HUMAN, A0A0A0MRJ6_HUMAN, A0A3F2YNX8_HUMAN, F6S8N6_HUMAN, B7Z972_HUMAN
UniprotKB: P22061, A0A0A0MRJ6, A0A3F2YNX8, F6S8N6, B7Z972
UniParc: UPI0001915378, UPI0000D4C8CC, UPI0000163B61, UPI0001EECB1F, UPI0000E0A5E6, UPI000007187C
EMBL: S73905, M93008, AL355312, BC007501, U49740, CH471051, S73902, AK289724, AK304532, BC008748, D25546, D25547, S73903, M93009, D25545, D13892
Ensembl: ENSG00000120265
KO: hsa:5110
Nucleutide sequences
EMBL-CDS: AAH07501.1, EAW47786.1, AAC60639.2, AAH08748.1, AAA90933.1, BAA05028.1, BAA02991.1, AAC60640.1, BAA05030.1, AAB38386.1, AAA90934.1, BAA05029.1, BAF82413.1, AAC60641.2, BAH14208.1
Ensembl_TRS: ENST00000367384, ENST00000464889, ENST00000367378, ENST00000649295, ENST00000367380, ENST00000544496
Protein sequencees
Ensembl_PRO: ENSP00000356354, ENSP00000420813, ENSP00000356348, ENSP00000497235, ENSP00000356350, ENSP00000438247
RefSeq: NP_001347381.1, NP_001347385.1, NP_001238980.1, NP_001238981.1, NP_005380.2, NP_001238979.1, NP_001238982.1, XP_011534170.1, XP_024302219.1, NP_001238978.1
Others
UniRef100: UniRef100_P22061, UniRef100_A0A3F2YNX8, UniRef100_F6S8N6
UniRef90: UniRef90_P22061, UniRef90_F6S8N6, UniRef90_A0A5F9CTV5
UniRef50: UniRef50_A0A482X143, UniRef50_P22061
UniGene: Hs.279257
CCDS: CCDS59041.1

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