| Type | Description |
|---|---|
| Definition | ubiquitin specific peptidase 28 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:10:00 | Deubiquitinase USP28 inhibits ubiquitin ligase KLHL2-mediated uridine-cytidine kinase 1 degradation and confers sensitivity to 5'-azacytidine-resistant human leukemia cells. | 31938050 |
| 2020-10-31 13:16:00 | The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway. | 31604991 |
| 2020-07-11 11:43:00 | A non-canonical role of caspase-8 exploited by cancer cells to override the p53-dependent G2/M cell-cycle checkpoint through cleavage of USP28. | 31982308 |
| 2020-05-30 12:58:00 | The effect of USP28 on cell proliferation was mediated by regulating the expression of p53, p21 and p16(INK4a). | 30910399 |
| 2020-01-04 10:54:00 | Knockdown of USP28 enhanced the radiosensitivity of esophageal cancer cells by destabilizing c-Myc and enhancing the accumulation of HIF-1alpha. Therefore, USP28 may serve as a novel therapeutic target to overcome esophageal cancer radioresistance. | 30206969 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
UBP28_HUMAN,
B4E3L3_HUMAN
UniprotKB:
Q96RU2,
B4E3L3
UniParc:
UPI0000137A00,
UPI00001FA3B0,
UPI00017A8736,
UPI000023B7E6
EMBL:
AP001874,
AF266283,
AP003170,
CH471065,
AK304770,
AB040948,
BC065928,
EF445045,
KF459544,
KF455523
Ensembl:
ENSG00000048028
KO:
hsa:57646
|
| Nucleutide sequences |
EMBL-CDS:
ACA06099.1,
AAK58565.1,
ACA06098.1,
BAA96039.1,
EAW67232.1,
AAH65928.1,
BAG65525.1
Ensembl_TRS:
ENST00000537706,
ENST00000003302,
ENST00000545540
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000445743,
ENSP00000003302,
ENSP00000444991
RefSeq:
NP_001333201.1,
NP_001333190.1,
NP_001333197.1,
NP_001333202.1,
NP_001333199.1,
NP_001333193.1,
NP_001333181.1,
NP_001333200.1,
NP_001287958.1,
NP_001333191.1,
NP_001333187.1,
NP_001333188.1,
NP_001333183.1,
NP_001333198.1,
NP_001333182.1,
NP_001333196.1,
NP_001333186.1,
NP_001333194.1,
NP_001333184.1,
NP_001333192.1,
NP_001333189.1,
NP_065937.1
|
| Others |
UniRef100:
UniRef100_Q96RU2,
UniRef100_B4E3L3
UniRef90:
UniRef90_Q96RU2,
UniRef90_Q5I043
UniRef50:
UniRef50_Q96RU2
UniGene:
Hs.503891
CCDS:
CCDS86248.1,
CCDS31680.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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