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81892 SLIRP

81892

SLIRP

SRA stem-loop interacting RNA binding protein

protein-coding

Homo sapiens

基因描述

Type Description
Definition SRA stem-loop interacting RNA binding protein

研究结论

Date Results Publications
2020-11-21 13:13:00 Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen. 31819114
2018-09-08 11:47:00 Study demonstrated that the LRPPRC-SLIRP complex is a global RNA chaperone that stabilizes RNA structures to expose the required sites for translation, stabilization, and polyadenylation. 29146908
2018-06-16 11:56:00 assessed, by using CRISPR-Cas9-introduced affinity tag and ChIP-Seq analysis, the genome-wide occupancy of SLIRP, and showed that the protein binds preferentially to G-rich DNA sequences that can fold into G4 structures 28859475
2017-06-10 11:55:00 LRPPRC displays a broad and strong RNA binding capacity in vitro in contrast to SLIRP that associates only weakly with RNA. 27353330
2016-12-17 11:48:00 Although SLIRP is not involved in mediating bcl-2 ability to protect from apoptosis and oxidative damage, bcl-2 binds and stabilizes SLIRP protein and regulates mitochondrial mRNA levels. The BH4 domain of bcl-2 has a role in maintaining this binding. 26866271

名称对应

Type IDs
Synonymous C14orf156, DC50, PD04872
Gene
UniProtKB-ID: SLIRP_HUMAN, A0A087WUN7_HUMAN
UniprotKB: Q9GZT3, A0A087WUN7
UniParc: UPI00001FD946, UPI00001FD945, UPI00000527C9
EMBL: AF271779, AC008044, AY860853, AF253980, BC017895, BU535760, AC008372, AJ272055
Ensembl: ENSG00000119705
KO: hsa:81892
Nucleutide sequences
EMBL-CDS: AAG44790.1, AAH17895.1, CAC81241.1, AAX58600.1, AAG44629.1
Gene_ORFName: PD04872, DC23, DC50
Ensembl_TRS: ENST00000557342, ENST00000238688, ENST00000613856
Protein sequencees
Ensembl_PRO: ENSP00000238688, ENSP00000450909, ENSP00000478794
RefSeq: NP_001254793.1, NP_001254792.1, NP_112487.1
Others
UniRef100: UniRef100_A0A087WUN7, UniRef100_Q9GZT3
UniRef90: UniRef90_Q9GZT3
UniRef50: UniRef50_Q9GZT3
UniGene: Hs.655105
CCDS: CCDS58331.1, CCDS9866.1

全选

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