| Type | Description |
|---|---|
| Definition | splicing factor 3b subunit 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-06 10:19:00 | SF3B2 is a critical determinant of AR-V7 expression and is correlated with aggressive cancer phenotypes. Pladienolide B, an inhibitor of a splicing modulator of the SF3b complex, suppressed the growth of tumors addicted to high SF3B2 expression. SF3B2 is a critical determinant of RNA splicing and gene expression patterns and controls the expression of key genes associated with CRPC progression, such as AR-V7. | 31431456 |
| 2018-10-06 10:47:00 | Splicing complex SF3B depletion impairs DNA end resection and hampers homologous recombination repair. SF3B controls CtIP function at, as least, two levels: by affecting CtIP mRNA levels and controlling CtIP recruitment to DNA breaks, in a way that requires ATM-mediated phosphorylation of SF3B2 at serine 289. | 29705135 |
| 2017-07-15 10:11:00 | a docking model based on NOESY measurements suggests that residues 607-616 of the SF3b145 fragment adopt a helical structure that binds to RRM1 predominantly via alpha1, consequently exhibiting a helix-helix interaction in almost antiparallel. | 27862552 |
| 2016-03-19 11:35:00 | High SF3B2 expression is associated with hepatocellular carcinoma. | 25731616 |
| 2015-10-31 10:25:00 | Although amino acid substitutions of residues surrounding Arg-508 had no great effect on PRMT9 recognition of SF3B2, moving the arginine residue within this sequence abolished methylation. | 25979344 |
| Type | IDs |
|---|---|
| Synonymous | Cus1, SAP145, SF3B145, SF3b1, SF3b150 |
| Gene |
UniProtKB-ID:
SF3B2_HUMAN
UniprotKB:
Q13435
UniParc:
UPI00001C1F20
EMBL:
BC000401,
AK290850,
BC007610,
AK300016,
BC053577,
BC014125,
U41371
Ensembl:
ENSG00000087365
KO:
hsa:10992
|
| Nucleutide sequences |
EMBL-CDS:
BAF83539.1,
BAG61831.1,
AAA97461.1,
AAH14125.2,
AAH07610.1,
AAH53577.1,
AAH00401.2
Ensembl_TRS:
ENST00000322535
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000318861
RefSeq:
XP_011543042.1,
NP_006833.2,
XP_005273783.1,
XP_016872633.1
|
| Others |
UniRef100:
UniRef100_Q13435
UniRef90:
UniRef90_Q13435
UniRef50:
UniRef50_Q13435
UniGene:
Hs.406423
CCDS:
CCDS31612.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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