| Type | Description |
|---|---|
| Definition | cleavage and polyadenylation specific factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:55:00 | Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration. | 33469008 |
| 2020-02-08 10:08:00 | Heterozygous loss-of-function mutations in CPSF1 are associated with early-onset high myopia and that CPSF1 may play an important role in the development of retinal ganglion cell axon projection. | 30689892 |
| 2019-07-27 10:43:00 | cryo-electron microscopic analysis of a core CPSF module bound to the polyadenylation signal hexamer motif | 29358758 |
| 2018-08-11 11:48:00 | Knockdown of CPSF inhibits the proliferation, migration and invasion of ovarian carcinoma cells. | 29358555 |
| 2018-08-11 11:13:00 | The authors define the molecular architecture of the core human CPSF complex comprising CPSF160, WDR33, CPSF30 and Fip1 and identify specific domains involved in inter-subunit interactions. Together, these results shed light on the function of CPSF in mediating polyA signal-dependent RNA cleavage and polyadenylation. | 29274231 |
| Type | IDs |
|---|---|
| Synonymous | CPSF160, HSU37012, P/cl.18 |
| Gene |
UniProtKB-ID:
CPSF1_HUMAN
UniprotKB:
Q10570
UniParc:
UPI00001282EE
EMBL:
BC017232,
U37012
Ensembl:
ENSG00000071894,
ENSG00000285049
KO:
hsa:29894
|
| Nucleutide sequences |
EMBL-CDS:
AAC50293.1,
AAH17232.1
Ensembl_TRS:
ENST00000643746,
ENST00000620219,
ENST00000644539,
ENST00000616140
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000484669,
ENSP00000478145,
ENSP00000495020,
ENSP00000495102
RefSeq:
XP_024302908.1,
XP_024302907.1,
XP_024302910.1,
XP_024302909.1,
XP_006716611.1,
NP_037423.2
|
| Others |
UniRef100:
UniRef100_Q10570
UniRef90:
UniRef90_Q10570
UniRef50:
UniRef50_Q10570
UniGene:
Hs.493202
CCDS:
CCDS34966.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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