| Type | Description |
|---|---|
| Definition | DNA fragmentation factor subunit beta |
| Date | Results | Publications |
|---|---|---|
| 2018-12-22 11:16:00 | Glandular, menopause-independent DFF40, DFF45, and Bcl-2 overexpression may play an important role in the pathogenesis of endometrial polyps and benign endometrial hyperplasia | 28914671 |
| 2018-06-29 13:17:00 | we show that executioner caspase activation of the apoptotic nuclease CAD/DFF40 is essential for TRAIL-induced mutations in surviving cells. As exposure to chemotherapy drugs also activates apoptotic caspases and presumably CAD, we hypothesized that these pathways may also contribute to the mutagenesis induced by conventional chemotherapy drugs, perhaps augmenting the mutations that arise from direct DNA damage | 28981092 |
| 2018-01-06 12:48:00 | Dff40 expression is upregulated in atherosclerotic plaque. | 28007744 |
| 2017-10-14 12:00:00 | the low expression levels of DFF40/CAD and the absence of DNA laddering as common molecular traits in glioblastoma | 26755073 |
| 2016-09-17 11:42:00 | Data suggest DFF40 expression in breast cancer cell line is involved in drug sensitivity/resistance to doxorubicin; apoptotic cell death due to doxorubicin (a topoisomerase II inhibitor) is enhanced by DFF40 overexpression in breast cancer cell line. | 26529233 |
| Type | IDs |
|---|---|
| Synonymous | CAD, CPAN, DFF-40, DFF2, DFF40 |
| Gene |
UniProtKB-ID:
DFFB_HUMAN,
Q96P74_HUMAN,
Q96P72_HUMAN,
B4DZS0_HUMAN,
Q96P73_HUMAN
UniprotKB:
O76075,
Q96P74,
Q96P72,
B4DZS0,
Q96P73
UniParc:
UPI000006DA14,
UPI000002A7D7,
UPI000006EED3,
UPI000006CF57,
UPI000006230F,
UPI000002A7D8,
UPI000002A7D9,
UPI00017A851D
EMBL:
AL691523,
AF064019,
AF409062,
BC032827,
AB028911,
AK290877,
AK303065,
AB013918,
AF039210,
BC048797,
CH471130,
AF409060,
AB028912,
AB028913,
AF409061
Ensembl:
ENSG00000169598
KO:
hsa:1677
|
| Nucleutide sequences |
EMBL-CDS:
BAB40447.1,
AAC39709.1,
BAB40448.1,
AAH48797.1,
BAA32250.1,
BAB40449.1,
AAC39920.1,
BAF83566.1,
AAL02005.1,
AAL02007.1,
BAG64182.1,
AAH32827.1,
AAL02006.1,
EAW71489.1
Gene_ORFName:
hCG_31570
Ensembl_TRS:
ENST00000491998,
ENST00000339350,
ENST00000378209,
ENST00000378206,
ENST00000338895,
ENST00000475969,
ENST00000468793
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000436775,
ENSP00000367454,
ENSP00000343218,
ENSP00000367448,
ENSP00000339524,
ENSP00000463688,
ENSP00000463704
RefSeq:
NP_001307061.1,
NP_001269598.1,
NP_001307065.1,
NP_004393.1,
XP_016855989.1,
XP_016855988.1,
XP_011539167.1,
XP_016855987.1
|
| Others |
UniRef100:
UniRef100_B4DZS0,
UniRef100_Q96P73,
UniRef100_Q96P74,
UniRef100_O76075
UniRef90:
UniRef90_O76075,
UniRef90_B4DZS0,
UniRef90_Q96P73
UniRef50:
UniRef50_O76075-3,
UniRef50_O76075,
UniRef50_B4DZS0
UniGene:
Hs.133089
CCDS:
CCDS52.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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