| Type | Description |
|---|---|
| Definition | RIO kinase 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-02 12:20:00 | Results describe three atomic structures of RIO2 kinase showing that it forms homodimer in vitro. Upon self-association, each protomer ATP-binding pocket is partially remodeled. The homodimerization is mediated by key residues previously shown to be responsible for ATP binding and catalysis. This data reveals an intricate mechanism where identical residues are involved in substrate binding and oligomeric state formation. | 31390939 |
| 2018-10-06 10:10:00 | These results suggested that RIOK2 and NOB1 may be potential targets in the treatment of Non-small cell lung cancer (NSCLC), and miR145 may be considered a therapeutic inhibitor of both genes. | 29749434 |
| 2018-05-12 11:03:00 | RIOK2 and NOB1 were highly expressed in NSCLC cells and tissues, and their expression profiles were significantly associated with the Tumour Node Metastasis (TNM) clinical stage, lymph node metastasis, and differentiation. RIOK2 expression was correlated with NOB1. | 27346559 |
| 2015-12-12 11:16:00 | As RIO2 is involved in the biosynthesis of the ribosome and cell cycle regulation, our selective ligand may be useful for the delineation of the biological role of this kinase. | 25891899 |
| 2013-06-15 11:33:00 | reduced expression of RIOK1 or RIOK2 disrupted Akt signaling and caused cell cycle exit, apoptosis, and chemosensitivity in glioblastoma cells | 23459592 |
| Type | IDs |
|---|---|
| Synonymous | RIO2 |
| Gene |
UniProtKB-ID:
RIOK2_HUMAN
UniprotKB:
Q9BVS4
UniParc:
UPI0001639BD6,
UPI000013DD20
EMBL:
AC008865,
AK225348,
AK002021,
BC000953,
AC008883
Ensembl:
ENSG00000058729
KO:
hsa:55781
|
| Nucleutide sequences |
EMBL-CDS:
AAH00953.1,
BAA92040.1
Ensembl_TRS:
ENST00000283109,
ENST00000508447
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000420932,
ENSP00000283109
RefSeq:
XP_016865117.1,
NP_060813.2,
NP_001153221.1
|
| Others |
UniRef100:
UniRef100_Q9BVS4
UniRef90:
UniRef90_Q9BVS4
UniRef50:
UniRef50_Q9BVS4
UniGene:
Hs.27021
CCDS:
CCDS4089.1,
CCDS54884.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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