| Type | Description |
|---|---|
| Definition | spen family transcriptional repressor |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:43:00 | SPEN induces miR-4652-3p to target HIPK2 in nasopharyngeal carcinoma. | 32641685 |
| 2021-03-27 14:40:00 | SPEN haploinsufficiency causes a neurodevelopmental disorder overlapping proximal 1p36 deletion syndrome with an episignature of X chromosomes in females. | 33596411 |
| 2018-05-12 11:57:00 | our data demonstrate a role for SPEN in the regulation of primary cilia formation and cell migration in breast cancer cells, which may collectively explain why its expression is associated with time to metastasis in cohorts of patients with ERalpha-negative breast cancers. | 28877752 |
| 2016-02-13 10:07:00 | SPEN is a novel tumor-suppressor gene that may be clinically useful as a predictive biomarker of tamoxifen response in ERalpha-positive breast cancers. | 26297734 |
| 2015-10-17 11:43:00 | SPEN mutations were associated with diffuse large B-cell lymphoma with hepatitis C virus infection. | 25381127 |
| Type | IDs |
|---|---|
| Synonymous | HIAA0929, MINT, RBM15C, SHARP |
| Gene |
UniProtKB-ID:
MINT_HUMAN
UniprotKB:
Q96T58
UniParc:
UPI000006FF0C
EMBL:
AF356524,
AL450998,
AB023146,
AK000882,
AL096858,
AL034555,
AK022949
Ensembl:
ENSG00000065526
KO:
hsa:23013
|
| Nucleutide sequences |
EMBL-CDS:
AAK52750.1,
CAB51072.1,
BAA76773.1,
BAA91405.1,
BAB14324.1
Ensembl_TRS:
ENST00000375759
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000364912
RefSeq:
NP_055816.2
|
| Others |
UniRef100:
UniRef100_Q96T58
UniRef90:
UniRef90_Q96T58
UniRef50:
UniRef50_Q96T58
UniGene:
Hs.744843
CCDS:
CCDS164.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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