| Type | Description |
|---|---|
| Definition | signal recognition particle 68 |
| Date | Results | Publications |
|---|---|---|
| 2019-10-12 10:55:00 | e show that SRP RNA does not bind to the ribosome, while SRP binds with nanomolar affinity involving a two-step mechanism of the key-player SRP54. Ultrasensitive binding of SRP68/72 indicates avidity by multiple binding sites that are dominated by the C-terminus of SRP72 | 30649417 |
| 2018-04-07 10:51:00 | The essential role of the SRP68-SRP72 interaction in the signal recognition particle-mediated protein translocation | 28369529 |
| 2017-06-10 10:58:00 | The crystal structures of the SRP68 protein-binding domain (PBD) in complex with SRP72-PBD and of the SRP72-RBD bound to the SRP S domain (SRP RNA, SRP19 and SRP68) detailing all interactions of SRP72 within SRP have been presented. | 27899666 |
| 2014-04-26 10:43:00 | study presents the crystal structures of the RNA-binding domain of SRP68 (SRP68-RBD) alone and in complex with SRP RNA and SRP19; data provide the structural basis for eukaryote-specific, SRP68-driven RNA remodeling required for protein translocation | 24700861 |
| 2013-03-02 13:12:00 | SRP68/72 heterodimers as major nuclear proteins whose binding of histone H4 tail is inhibited by H4R3 methylation. | 23048028 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
SRP68_HUMAN
UniprotKB:
Q9UHB9
UniParc:
UPI0000EE5CED,
UPI0000071582,
UPI0000EE5D2E,
UPI000006EAEC
EMBL:
CH471099,
AK126258,
BC020238,
AC040980,
AK074698,
AF195951,
AK097962
Ensembl:
ENSG00000167881
KO:
hsa:6730
|
| Nucleutide sequences |
EMBL-CDS:
BAG54299.1,
EAW89360.1,
BAG53557.1,
AAF24308.1,
AAH20238.1,
EAW89362.1,
BAC11145.1
Ensembl_TRS:
ENST00000602720,
ENST00000539137,
ENST00000307877
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000446136,
ENSP00000473613,
ENSP00000312066
RefSeq:
NP_001247431.1,
NP_055045.2,
NP_001247432.1
|
| Others |
UniRef100:
UniRef100_Q9UHB9
UniRef90:
UniRef90_Q9UHB9
UniRef50:
UniRef50_Q9UHB9
UniGene:
Hs.514495
CCDS:
CCDS58601.1,
CCDS58600.1,
CCDS11738.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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