| Type | Description |
|---|---|
| Definition | protein kinase cAMP-dependent type I regulatory subunit alpha |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:25:00 | PRKAR1A deficiency impedes hypertrophy and reduces heart size. | 32212257 |
| 2021-03-13 13:20:00 | Unbiased Proteomic Profiling Uncovers a Targetable Axis in Small Cell Lung Cancer Stem Cells. | 32531271 |
| 2020-11-21 13:32:00 | Link between steroidogenesis, the cell cycle, and in adrenocortical tumor cells. | 31678420 |
| 2020-03-28 11:16:00 | Biochemical studies demonstrate how the removal of ATP primes the holoenzyme for cAMP-mediated activation. The opposing competition between ATP/cAMP is unique to RIalpha..Comparisons to the RIIb holoenzyme demonstrate isoform-specific holoenzyme interfaces and highlights distinct allosteric mechanisms for activation in addition to the structural diversity of the isoforms | 31363049 |
| 2020-03-07 12:16:00 | PRKAR1A plays a role in the development of a subset of conjunctival myxomas, particularly in tumors fulfilling stringent morphologic criteria for myxoma. | 31078543 |
| Type | IDs |
|---|---|
| Synonymous | ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1 |
| Gene |
UniProtKB-ID:
KAP0_HUMAN,
B2R5T5_HUMAN
UniprotKB:
P10644,
B2R5T5
UniParc:
UPI000040A1C2,
UPI0000001C57
EMBL:
BC036285,
BC093042,
S54707,
S54711,
AK312307,
AK097580,
GQ901048,
S54709,
S54705,
AC079210,
M18468,
M33336,
Y07642,
CH471099
Ensembl:
ENSG00000108946
KO:
hsa:5573
|
| Nucleutide sequences |
EMBL-CDS:
AAH93042.1,
AAB50921.1,
AAB50922.1,
AAH36285.1,
CAA68925.1,
EAW89062.1,
BAG35232.1,
EAW89061.1,
EAW89060.1,
EAW89065.1,
BAG53489.1,
ADO22565.1,
EAW89063.1
Gene_ORFName:
hCG_28462
Ensembl_TRS:
ENST00000588188,
ENST00000392711,
ENST00000358598,
ENST00000536854,
ENST00000589228,
ENST00000586397
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000464977,
ENSP00000468106,
ENSP00000376475,
ENSP00000466459,
ENSP00000445625,
ENSP00000351410
RefSeq:
NP_001263218.1,
NP_001265362.1,
NP_001356319.1,
NP_997636.1,
NP_001356318.1,
NP_002725.1,
NP_997637.1,
NP_001263219.1,
XP_011523286.1
|
| Others |
UniRef100:
UniRef100_P10644
UniRef90:
UniRef90_P10644
UniRef50:
UniRef50_P10644
UniGene:
Hs.280342,
Hs.745160
CCDS:
CCDS62307.1,
CCDS11678.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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