| Type | Description |
|---|---|
| Definition | cyclin dependent kinase 7 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:54:00 | Targeting CDK7 increases the stability of Snail to promote the dissemination of colorectal cancer. | 30451989 |
| 2020-08-01 13:20:00 | combining THZ1 with a BCL2/BCL-XL inhibitor ABT-263 synergized in impairing cell growth and driving apoptosis. Our results demonstrate CDK7 as a potential target in treating CCA. Combinations of CDK7 inhibition and BCL2/BCL-XL inhibition may offer a novel therapeutic strategy for CCA. | 31399555 |
| 2020-06-20 10:16:00 | our findings reveal a novel therapeutic strategy of pharmacological inhibitions of BRD4 and CDK7 against head and neck squamous cell carcinoma. | 31765738 |
| 2020-04-25 12:24:00 | Dual HER2 and CDK7 inhibition induced tumor regression in two HER2iR BC xenograft models in vivo. Our data support the utilization of CDK7 inhibition as an additional therapeutic avenue that blocks the activation of genes engaged by multiple HER2iR kinases. | 31462705 |
| 2019-10-05 12:14:00 | In this study Hep3B and Huh7 cells were infected with two CDK7 shRNAs, both of which reduced CDK7 levels. Inhibition of CDK7 impaired proliferation of Hep3B and Huh7 cells in both short-term IncuCyte(R) cell proliferation assays and long-term colony formation assays. | 29507396 |
| Type | IDs |
|---|---|
| Synonymous | CAK, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15 |
| Gene |
UniProtKB-ID:
CDK7_HUMAN,
A0A0S2Z3F9_HUMAN,
D6RFL0_HUMAN,
D6R9G1_HUMAN
UniprotKB:
P50613,
A0A0S2Z3F9,
D6RFL0,
D6R9G1
UniParc:
UPI0001D3B3FA,
UPI0000127431,
UPI0001D3B3FE
EMBL:
Y13120,
CH471137,
AY130859,
X79193,
X77743,
KU177971,
X77303,
KU177970,
L20320,
AC145132,
AC093223,
BC000834,
AC145145,
BC005298
Ensembl:
ENSG00000134058,
ENSG00000277273
KO:
hsa:1022
|
| Nucleutide sequences |
EMBL-CDS:
CAA54508.1,
AAH00834.1,
CAA73587.1,
AAA36657.1,
AAM77799.1,
CAA55785.1,
AAH05298.1,
CAA54793.1,
EAW51300.1,
ALQ33428.1,
ALQ33429.1
Gene_ORFName:
hCG_1988840
Ensembl_TRS:
ENST00000256443,
ENST00000615305,
ENST00000510106,
ENST00000615854,
ENST00000614858,
ENST00000502604
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000256443,
ENSP00000479116,
ENSP00000426561,
ENSP00000479440,
ENSP00000422121,
ENSP00000478687
RefSeq:
NP_001310999.1,
NP_001311000.1,
NP_001311001.1,
NP_001311003.1,
NP_001311007.1,
NP_001311004.1,
NP_001790.1,
NP_001310998.1,
XP_011541396.1,
NP_001311006.1
|
| Others |
UniRef100:
UniRef100_D6RFL0,
UniRef100_P50613
UniRef90:
UniRef90_P50613,
UniRef90_A0A2K6GZ34
UniRef50:
UniRef50_P50613,
UniRef50_Q9C9M7
UniGene:
Hs.184298
CCDS:
CCDS3999.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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