| Type | Description |
|---|---|
| Definition | sorting nexin 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 10:11:00 | sorting nexin SNX3 is transported with Rab5a vesicles and that its PX domain enables vesicle-phagosome contact by binding to PI(3)P in the phagosomal coat. Moreover, the C-terminal region of SNX3 recruits galectin-9, a lectin implicated in protein and membrane recycling, which we identify as a further regulator of phagosome compaction. | 31337623 |
| 2019-01-12 12:11:00 | SNX3 regulates amyloid beta production by influencing the internalization of amyloid precursor protein in HEK293T cells and may have a role in the pathogenesis of Alzheimer's disease. | 29414832 |
| 2019-01-05 10:44:00 | an evolutionary conserved MON2:DOPEY2:ATP9A complex is required for SNX3 retromer mediation of Wntless sorting and Wnt secretion | 30213940 |
| 2017-10-21 10:28:00 | SNX3-retromer complex regulates the surface expression and function of PC1 and PC2 | 28620080 |
| 2017-05-13 13:44:00 | X-ray crystallographic analysis of a 4-component complex comprising the VPS26 & VPS35 subunits of retromer, sorting nexin SNX3, & recycling signal from the divalent cation transporter DMT1-II; analysis identifies a binding site for canonical recycling signals at the interface between VPS26 & SNX3; shows cooperative interactions among the VPS subunits, SNX3 & cargo that couple signal-recognition to membrane recruitment. | 27889239 |
| Type | IDs |
|---|---|
| Synonymous | Grd19, MCOPS8, SDP3 |
| Gene |
UniProtKB-ID:
SNX3_HUMAN
UniprotKB:
O60493
UniParc:
UPI0000470A0E,
UPI00000013A7,
UPI000006E5DF,
UPI000002B3E6
EMBL:
AF062483,
CR456898,
Z98742,
BC014580,
BC016863,
BT007114,
AB047360,
AL078596,
AK289476,
BC015179,
AF034546,
CH471051,
BC008444
Ensembl:
ENSG00000112335
KO:
hsa:8724
|
| Nucleutide sequences |
EMBL-CDS:
EAW48378.1,
AAH08444.1,
BAF82165.1,
AAH14580.1,
BAB32649.1,
AAH15179.1,
CAG33179.1,
AAH16863.1,
AAC16040.1,
AAP35778.1,
EAW48382.1,
AAC16018.1,
EAW48381.1,
EAW48379.1
Ensembl_TRS:
ENST00000426155,
ENST00000368979,
ENST00000230085,
ENST00000349379
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000296991,
ENSP00000357975,
ENSP00000230085,
ENSP00000401779
RefSeq:
NP_690040.1,
NP_001287857.1,
NP_001287858.1,
NP_003786.1
|
| Others |
UniRef100:
UniRef100_O60493
UniRef90:
UniRef90_O60493
UniRef50:
UniRef50_O60493
UniGene:
Hs.12102
CCDS:
CCDS5064.1,
CCDS75501.1,
CCDS5065.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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