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2887 GRB10

2887

GRB10

growth factor receptor bound protein 10

protein-coding

Homo sapiens

基因描述

Type Description
Definition growth factor receptor bound protein 10

研究结论

Date Results Publications
2020-05-09 12:14:00 inhibition of mTORC1 with rapamycin blocked Grb10 Ser476 phosphorylation and repressed a negative-feedback loop on PI3K/Akt signaling that increased myotube responsiveness to insulin 31794259
2019-11-23 10:57:00 results suggest that GRB10 acts as a major downstream effector of PI3K and has tumor-promoting effects in prostate cancer 30379590
2019-03-16 12:18:00 Using state-of-the-art patient-derived hormone-naive prostate cancer xenograft models,we found and validated the growth factor receptor bound protein 10 gene as a driver of CRPC. 29544736
2018-04-28 11:41:00 Through syngeneic comparison, our study identifies for the first time that Grb10 is associated with the pluripotency state in nuclear transfer embryonic stem cells. 28476045
2017-11-11 11:54:00 Study found FGFR3 gene mutation plus GRB10 gene duplication in a patient with achondroplasia plus growth delay with prenatal onset 27370225

名称对应

Type IDs
Synonymous GRB-IR, Grb-10, IRBP, MEG1, RSS
Gene
UniProtKB-ID: GRB10_HUMAN
UniprotKB: Q13322
UniParc: UPI000002AAC1, UPI000000127A, UPI000012BA84, UPI000013D5BF
EMBL: BC024285, AF073365, CH471128, AB000731, AF073371, D86962, AF073366, AF073367, U69276, AF073372, AJ271366, AF073374, AF073363, AF073373, AF073364, AF073377, AF073376, AF073378, U34355, AF073368, CH236955, AF073369, AF000017, AF001534, U66065, AC005153, AF073370, AK289511, AF073375
Ensembl: ENSG00000106070
KO: hsa:2887
Nucleutide sequences
EMBL-CDS: AAA88819.1, EAW60965.1, AAH24285.1, AAC83654.1, EAW60964.1, AAB81134.1, AAC83655.1, EAL23897.1, AAC19748.1, BAF82200.1, CAB96542.1, AAB08431.1, BAF76353.1, BAA13198.2, AAC50671.1, EAW60967.1
Ensembl_TRS: ENST00000406641, ENST00000407526, ENST00000402578, ENST00000401949, ENST00000402497, ENST00000403097, ENST00000335866, ENST00000357271, ENST00000645075, ENST00000398812, ENST00000643299, ENST00000398810
Protein sequencees
Ensembl_PRO: ENSP00000349818, ENSP00000495341, ENSP00000381790, ENSP00000381793, ENSP00000385366, ENSP00000385189, ENSP00000385748, ENSP00000385770, ENSP00000385046, ENSP00000385544, ENSP00000496245, ENSP00000338543
RefSeq: XP_016867522.1, XP_016867557.1, NP_001001550.1, XP_016867528.1, XP_011513618.1, NP_001357937.1, XP_016867545.1, XP_016867544.1, XP_016867538.1, XP_016867547.1, XP_016867527.1, XP_024302496.1, NP_001357938.1, NP_001337745.2, XP_016867548.1, XP_016867536.1, XP_016867532.1, XP_016867537.1, XP_016867542.1, XP_016867553.1, XP_016867539.1, XP_016867543.1, XP_011513625.1, XP_016867554.1, XP_016867526.1, XP_016867529.1, XP_016867552.1, XP_016867535.1, XP_016867551.1, XP_016867556.1, NP_001001549.1, XP_024302494.1, NP_001001555.1, XP_016867550.1, XP_016867519.1, XP_016867523.1, XP_016867521.1, XP_016867534.1, XP_024302497.1, XP_016867518.1, NP_001337743.1, NP_001337744.1, XP_016867531.1, XP_016867520.1, XP_024302498.1, XP_016867525.1, XP_016867549.1
Others
UniRef100: UniRef100_Q13322
UniRef90: UniRef90_Q13322
UniRef50: UniRef50_Q13322
UniGene: Hs.164060
CCDS: CCDS87503.1, CCDS47586.1, CCDS43582.1, CCDS43583.1

全选

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