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51726 DNAJB11

51726

DNAJB11

DnaJ heat shock protein family (Hsp40) member B11

protein-coding

Homo sapiens

基因描述

Type Description
Definition DnaJ heat shock protein family (Hsp40) member B11

研究结论

Date Results Publications
2020-07-18 11:31:00 These findings suggest that, under normal conditions, ERdj3 functions as an ER chaperone in complex with SDF2/SDF2L1 but is secreted into the extracellular space when it cannot form this complex. 31624144
2019-05-18 12:12:00 strong positive expression of DNAJB11 was an independent prognostic factor for disease-free survival and overall survival in epithelial ovarian cancer 28752709
2019-04-20 12:03:00 ERdj3 expression is enhanced in hepatocellular carcinoma (HCC) tumors and is positively associated with more inferior survival outcomes. ERdj3 promotes intracellular Z mutant of alpha-1-antitrypsin (AATZ) accumulation in HCC cells via suppressing post-transcriptional AATZ degradation and promotes HCC cell proliferation, epithelial-mesenchymal transition, migratory ability and invasiveness in an AATZ-dependent manner. 29992839
2018-12-22 10:13:00 DNAJB11-associated disease is a phenotypic hybrid of Autosomal-dominant polycystic kidney disease and autosomal-dominant tubulointerstitial diseases. 29706351
2017-12-23 12:56:00 ZAAT ER clearance resulted from enhancing ERdj3-mediated ZAAT degradation by silencing ERdj3 while simultaneously enhancing autophagy. In this context, ERdj3 suppression may eliminate the toxic gain of function associated with polymerization of ZAAT 28419579

名称对应

Type IDs
Synonymous ABBP-2, ABBP2, DJ9, Dj-9, EDJ, ERdj3, ERj3, ERj3p, PKD6, PRO1080, UNQ537
Gene
UniProtKB-ID: DJB11_HUMAN
UniprotKB: Q9UBS4
UniParc: UPI0000001BF7
EMBL: AY359043, AJ250137, CR457096, AB028859, AF277317, AF228505, AK075430, CH471052, BT007063, BC001144, AK075300
Ensembl: ENSG00000090520
KO: hsa:51726
Nucleutide sequences
EMBL-CDS: CAG33377.1, AAF61711.1, AAP35712.1, CAB65118.1, AAQ89402.1, AAH01144.1, BAA88307.1, AAK69110.1, EAW78190.1, BAC11617.1, BAC11533.1
Gene_ORFName: UNQ537/PRO1080, PSEC0121
Ensembl_TRS: ENST00000265028, ENST00000439351
Protein sequencees
Ensembl_PRO: ENSP00000265028, ENSP00000414398
RefSeq: NP_057390.1, NP_001365380.1
Others
UniRef100: UniRef100_Q9UBS4
UniRef90: UniRef90_Q9UBS4
UniRef50: UniRef50_Q9UBS4
UniGene: Hs.317192
CCDS: CCDS3277.1

全选

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