| Type | Description |
|---|---|
| Definition | mediator complex subunit 23 |
| Date | Results | Publications |
|---|---|---|
| 2019-09-07 11:44:00 | intra-tumor heterogeneity data suggest that there could be an under- or over-estimation of the occurrence of MED23 frameshift mutations in microsatellite instability-high colorectal cancers | 26152846 |
| 2018-12-22 11:08:00 | MED23 adopts an arch-shaped conformation, with an N-terminal domain (Nter) protruding from a large core region. | 30140054 |
| 2017-10-21 11:46:00 | This is the first patient with documented refractory epilepsy caused by a novel homozygous pathogenic variant in MED23 expanding the phenotypic spectrum. Identification of the underlying genetic defect in MED23 sheds light on the possible mechanism of complete response to the ketogenic diet in this child. | 27311965 |
| 2017-07-29 10:47:00 | a 7-gene signature was identified which correctly predicted the primary prefibrotic myelofibrosis group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, and MMP8 | 27579896 |
| 2017-05-27 11:52:00 | Higher l-arginine was associated with higher risk of Ischemic heart disease (odds ratio and of myocardial infarction, based on 2 SNPs from MED23. | 27914500 |
| Type | IDs |
|---|---|
| Synonymous | ARC130, CRSP130, CRSP133, CRSP3, DRIP130, MRT18, SUR-2, SUR2 |
| Gene |
UniProtKB-ID:
MED23_HUMAN,
Q05DL5_HUMAN
UniprotKB:
Q9ULK4,
Q05DL5
UniParc:
UPI000002A737,
UPI000191F62F,
UPI0000D491EE,
UPI00015C73ED,
UPI0000470A9D,
UPI000002A736,
UPI000012855F
EMBL:
AF104255,
AL121575,
EU392526,
AB033042,
BC060759,
AL136776,
AF135022,
AF105332,
BC007088,
CH471051
Ensembl:
ENSG00000112282
KO:
hsa:9439
|
| Nucleutide sequences |
EMBL-CDS:
AAH60759.1,
EAW48052.1,
CAB66710.1,
AAD31729.1,
AAD30202.1,
BAA86530.1,
ACB88854.1,
AAD12724.1,
AAH07088.1
Ensembl_TRS:
ENST00000368053,
ENST00000539158,
ENST00000368060,
ENST00000368068,
ENST00000354577
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000445072,
ENSP00000357032,
ENSP00000346588,
ENSP00000357047,
ENSP00000357039
RefSeq:
NP_001363446.1,
XP_006715675.1,
NP_001363447.1,
NP_001257451.1,
NP_001363452.1,
NP_057063.2,
NP_001363451.1,
NP_004821.2,
NP_001257450.1,
XP_016866990.1,
NP_001363449.1,
XP_011534559.1,
NP_001363450.1,
NP_001363448.1,
NP_001363453.1
|
| Others |
UniRef100:
UniRef100_Q9ULK4,
UniRef100_Q05DL5
UniRef90:
UniRef90_Q05DL5,
UniRef90_Q9ULK4
UniRef50:
UniRef50_Q9ULK4,
UniRef50_Q05DL5
UniGene:
Hs.29679
CCDS:
CCDS5147.1,
CCDS59039.1,
CCDS5146.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员