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7468 NSD2

7468

NSD2

nuclear receptor binding SET domain protein 2

protein-coding

Homo sapiens

基因描述

Type Description
Definition nuclear receptor binding SET domain protein 2

研究结论

Date Results Publications
2021-03-20 13:34:00 Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases. 33361816
2021-02-27 13:52:00 Targeting NSD2-mediated SRC-3 liquid-liquid phase separation sensitizes bortezomib treatment in multiple myeloma. 33589584
2021-01-16 16:00:00 The prognostic impact of tumour NSD2 expression in advanced prostate cancer. 32091270
2020-12-19 13:42:00 Twist-1 is upregulated by NSD2 and contributes to tumour dissemination and an epithelial-mesenchymal transition-like gene expression signature in t(4;14)-positive multiple myeloma. 32014459
2020-08-12 12:31:00 Study reports that DNA double-strand breaks (DSBs) promote NSD2-mediated dimethylation of PTEN at K349, which is read by the tudor domain of 53BP1 to recruit PTEN into DNA-damage sites to govern the timely repair of DSBs in part through dephosphorylating gammaH2AX. 31217297

名称对应

Type IDs
Synonymous KMT3F, KMT3G, MMSET, REIIBP, TRX5, WHS, WHSC1
Gene
UniProtKB-ID: NSD2_HUMAN
UniprotKB: O96028
UniParc: UPI0000D6152C, UPI0000073D15, UPI0000E5ABF7, UPI0000073F57, UPI00000719E4, UPI000019274F, UPI000007317B
EMBL: AF178219, AF178202, AK289697, AF178218, AF178201, AF083388, AB029013, AF178199, AF178216, AL132868, AF178214, AF083386, AF178207, AF178213, BC094825, AF178203, AF330040, AF178215, BC070176, AF083391, AF083390, BC152412, AF071593, AF178210, AF178212, AJ007042, AF178198, AF178217, AF178205, AC105448, AF178200, AF071594, AY694128, AF178206, AF178211, AF178209, BC141815, AF083387, BC052254, AF083389, AF178208, CH471131, AF178204
Ensembl: ENSG00000109685
KO: hsa:7468
Nucleutide sequences
EMBL-CDS: BAF82386.1, AAD19344.1, EAW82552.1, AAH94825.2, EAW82557.1, EAW82556.1, AAU09264.1, AAC24151.1, AAF23369.1, AAI41816.1, AAD19346.1, AAD19345.1, AAK00344.1, AAC24150.1, AAD19343.1, AAI52413.1, EAW82553.1, EAW82548.1, CAB45386.1, AAH70176.1, AAD21770.1, BAA83042.2, AAF23370.1, AAD21771.1, AAH52254.1
Ensembl_TRS: ENST00000312087, ENST00000353275, ENST00000503128, ENST00000382891, ENST00000420906, ENST00000436793, ENST00000508803, ENST00000382895, ENST00000514045, ENST00000382892, ENST00000382888, ENST00000512700, ENST00000398261
Protein sequencees
Ensembl_PRO: ENSP00000427516, ENSP00000372351, ENSP00000421681, ENSP00000372344, ENSP00000381311, ENSP00000308780, ENSP00000399251, ENSP00000372348, ENSP00000372347, ENSP00000423972, ENSP00000425761, ENSP00000416725, ENSP00000329167
RefSeq: XP_006713977.1, NP_579889.1, XP_011511862.1, XP_016864077.1, NP_579877.1, NP_001035889.1, NP_579878.1, XP_005248059.1, NP_015627.1, XP_016864076.1, XP_011511859.1, XP_005248062.1, XP_005248058.1, NP_579890.1
Others
UniRef100: UniRef100_O96028
UniRef90: UniRef90_O96028
UniRef50: UniRef50_O96028
UniGene: Hs.113876
CCDS: CCDS3356.1, CCDS33940.1, CCDS46999.1

全选

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