| Type | Description |
|---|---|
| Definition | ubiquitin conjugating enzyme E2 N |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:34:00 | Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler. | 33288957 |
| 2020-09-05 13:58:00 | Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination. | 32398758 |
| 2020-06-13 11:42:00 | Data show that miR-934 binds to a 3'-UTR of ubiquitin-conjugating enzyme 2N (ube2n) mRNA, down-regulated UBE2N protein expression; this, in turn, attenuated cyclin dependent kinase 6 (CDK6) protein degradation and led to CDK6 protein accumulation as well as the promotion of BC tumor growth. | 31373842 |
| 2020-05-09 11:56:00 | Deamidation elicited by Shigella flexneri disrupts native and transient contacts to weaken the interaction between UBC13 and TRAF6 and to silence the host anti-inflammatory response. | 31638574 |
| 2020-02-22 12:29:00 | Study reveals how TRIM21 facilitates ubiquitin transfer and differentiates this E2 from other closely related enzymes. A tri-ionic motif provides optimally distributed anchor points that allow TRIM21 to wrap an Ube2N~Ub complex around its RING domain. The tri-ionic motif is exclusively required for Ube2N but not Ube2D1 activity and provides a generic E2-specific catalysis mechanism for RING E3s. | 31582740 |
| Type | IDs |
|---|---|
| Synonymous | HEL-S-71, UBC13, UBCHBEN; UBC13, UbcH-ben, UbcH13 |
| Gene |
UniProtKB-ID:
UBE2N_HUMAN,
V9HW41_HUMAN
UniprotKB:
P61088,
V9HW41
UniParc:
UPI0000003EA3
EMBL:
BC000396,
BC003365,
BC108704,
CH471054,
FJ224354,
BT006873,
D83004
Ensembl:
ENSG00000177889
KO:
hsa:7334
|
| Nucleutide sequences |
EMBL-CDS:
AAP35519.1,
AAH00396.1,
AAH03365.1,
AAI08705.1,
BAA11675.1,
EAW97480.1,
ACI46046.1,
EAW97482.1,
EAW97481.1
Gene_ORFName:
hCG_38950
Ensembl_TRS:
ENST00000318066
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000316176
RefSeq:
NP_003339.1
|
| Others |
UniRef100:
UniRef100_P61088
UniRef90:
UniRef90_P61088
UniRef50:
UniRef50_P61088
UniGene:
Hs.524630
CCDS:
CCDS31875.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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