| Type | Description |
|---|---|
| Definition | diacylglycerol kinase alpha |
| Date | Results | Publications |
|---|---|---|
| 2021-01-02 12:51:00 | Diacylglycerol kinases regulate TRPV1 channel activity. | 32345612 |
| 2020-04-18 11:37:00 | Upon neutrophil stimulation, DGK-alpha activation is necessary for migration and a productive response. This paper focuses on the role of DGK-alpha in obstructive respiratory diseases, including asthma and chronic obstructive pulmonary disease, but also rare genetic diseases such as alpha-1-antitrypsin deficiency. [review] | 31766109 |
| 2020-04-11 12:09:00 | This study presents the first crystal structure of EF-hand domains of diacylglycerol kinase alpha in its Ca(2+) bound form and characterize Ca(2+) -induced conformational changes, which likely regulates intra-molecular interactions. | 30653270 |
| 2019-09-28 12:03:00 | This novel study demonstrates efficient ablation of diacylglycerol kinase in human CAR-T cells that leads to improved antitumor immunity and may have significant impact in human cancer immunotherapy | 29967261 |
| 2017-11-18 10:48:00 | Diacylglycerol kinases alpha and zeta are up-regulated in cancer in cancer, and contribute towards tumor immune evasion and T cells clonal anergy. (Review) | 27697466 |
| Type | IDs |
|---|---|
| Synonymous | DAGK, DAGK1, DGK-alpha |
| Gene |
UniProtKB-ID:
DGKA_HUMAN,
A0A024RB23_HUMAN
UniprotKB:
P23743,
A0A024RB23
UniParc:
UPI00005AB2A3,
UPI000007417B,
UPI0000072F7D
EMBL:
AF064769,
AF064768,
CH471054,
X62535,
AC025162,
BC023523,
BC031870,
AF064771,
AF064767,
AY930112
Ensembl:
ENSG00000065357
KO:
hsa:1606
|
| Nucleutide sequences |
EMBL-CDS:
AAC34806.1,
AAH23523.1,
AAC34804.1,
CAA44396.1,
AAY20994.1,
AAC34803.1,
AAC34802.1,
AAH31870.1,
EAW96851.1,
EAW96849.1
Gene_ORFName:
hCG_25001
Ensembl_TRS:
ENST00000553084,
ENST00000551156,
ENST00000548549,
ENST00000331886,
ENST00000394147,
ENST00000402956
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000448565,
ENSP00000450359,
ENSP00000377703,
ENSP00000385792,
ENSP00000328405,
ENSP00000446605
RefSeq:
NP_001336.2,
NP_958852.1,
XP_016874395.1,
XP_016874390.1,
NP_001337969.1,
NP_001337962.1,
NP_963848.1,
NP_001337966.1,
NP_001337965.1,
NP_001337967.1,
XP_016874393.1,
NP_001337968.1,
NP_001337964.1,
NP_001337963.1,
XP_016874392.1,
XP_016874397.1,
XP_016874389.1,
XP_016874396.1,
XP_016874391.1,
XP_011536295.1,
XP_016874394.1,
XP_005268746.1,
NP_958853.1,
XP_011536297.1
|
| Others |
UniRef100:
UniRef100_P23743
UniRef90:
UniRef90_P23743
UniRef50:
UniRef50_P23743
UniGene:
Hs.524488
CCDS:
CCDS8896.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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