| Type | Description |
|---|---|
| Definition | keratin 3 |
| Date | Results | Publications |
|---|---|---|
| 2018-10-06 10:19:00 | RT-PCR showed that K3 and K12 transcripts were absent from patient cells, but present in healthy control preparations. | 29162348 |
| 2016-12-24 11:46:00 | we show that the two PAX6 isoforms differentially and cooperatively regulate the expression of genes specific to the structure and functions of the corneal epithelium, particularly keratin 3 (KRT3) and keratin 12 (KRT12). PAX6 isoform-a induced KRT3 expression by targeting its upstream region. KLF4 enhanced this induction. A combination of PAX6 isoform-b, KLF4, and OCT4 induced KRT12 expression | 26899008 |
| 2014-01-18 12:01:00 | Exon sequencing of KRT3 and KRT12 in six affected and eight unaffected individuals did not detect any mutations or nucleotide sequence variants in Meesmann epithelial corneal dystrophy. | 23569037 |
| 2010-01-21 00:00:00 | A novel missense mutation (R503P) in KRT3 leads to MCD in 2 unrelated Taiwanese families. | 16227835 |
| 2010-01-21 00:00:00 | Location of the E498V mutation emphasizes the functional relevance of the highly conserved boundary motifs at the COOH-terminus of the alpha-helical rod domain in keratin 3 (K3). | 18806880 |
| Type | IDs |
|---|---|
| Synonymous | CK3, K3 |
| Gene |
UniProtKB-ID:
K2C3_HUMAN
UniprotKB:
P12035
UniParc:
UPI000013EEC8
EMBL:
AC107016,
X05419,
X05420,
AJ628418,
X05418,
X05421
Ensembl:
ENSG00000186442
KO:
hsa:3850
|
| Nucleutide sequences |
EMBL-CDS:
CAA28993.1,
CAA28995.1,
CAF31522.1,
CAA28994.1,
CAA28996.1,
CAA28992.1,
CAA28991.1
Ensembl_TRS:
ENST00000417996
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000413479
RefSeq:
NP_476429.2,
XP_024304743.1
|
| Others |
UniRef100:
UniRef100_P12035
UniRef90:
UniRef90_P12035
UniRef50:
UniRef50_P12035
UniGene:
Hs.680652
CCDS:
CCDS44895.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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