| Type | Description |
|---|---|
| Definition | CD2 associated protein |
| Date | Results | Publications |
|---|---|---|
| 2020-09-05 13:54:00 | Excessive apoptosis of podocytes caused by dysregulation of microRNA-182-5p and CD2AP confers to an increased risk of diabetic nephropathy. | 31131477 |
| 2020-06-13 10:32:00 | The authors demonstrate that CD2AP interaction with hypervariable domains of Chikungunya virus nsP3 is mediated by its SH3-A and SH3-C domains, and this leaves the SH3-B domain available for interaction with other cellular factor(s). | 31493651 |
| 2020-04-25 12:32:00 | tyrosine in position Y10 of the SH3-1 domain of CD2AP is indispensable for CD2AP function in vivo. | 31235616 |
| 2020-04-25 11:48:00 | The upregulation of CD2-associated protein (CD2AP) could attenuate gastric cancer (GC) metastasis, suggesting CD2AP as a biomarker for the prognosis and treatment of patients with GC. | 31989722 |
| 2019-08-24 12:20:00 | Study identified a homozygous frameshift mutation in CD2AP (p.S198fs) in three siblings born of consanguineous parents who developed childhood-onset focal segmental glomerulosclerosis (FSGS) and end stage renal disease. When the same mutation was introduced in mice by gene editing, the mice developed FSGS and kidney failure. These results provide conclusive evidence that homozygous mutation of CD2AP causes FSGS in humans. | 30612599 |
| Type | IDs |
|---|---|
| Synonymous | CMS |
| Gene |
UniProtKB-ID:
CD2AP_HUMAN
UniprotKB:
Q9Y5K6
UniParc:
UPI000006F8C1
EMBL:
AF146277,
CH471081,
AF164377,
BC069444,
AL355353,
AL050105,
AL358178
Ensembl:
ENSG00000198087
KO:
hsa:23607
|
| Nucleutide sequences |
EMBL-CDS:
EAX04319.1,
AAH69444.1,
AAD34595.1,
CAB43274.1,
AAF80495.1
Ensembl_TRS:
ENST00000359314
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000352264
RefSeq:
NP_036252.1,
XP_011512751.1,
XP_016866130.1,
XP_005249033.1
|
| Others |
UniRef100:
UniRef100_Q9Y5K6
UniRef90:
UniRef90_Q9Y5K6
UniRef50:
UniRef50_Q9Y5K6
UniGene:
Hs.485518
CCDS:
CCDS34472.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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