| Type | Description |
|---|---|
| Definition | leucine rich repeat containing 8 VRAC subunit A |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:34:00 | LRRC8A homohexameric channels poorly recapitulate VRAC regulation and pharmacology. | 33356947 |
| 2021-02-02 13:28:00 | LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses. | 33139539 |
| 2020-10-10 12:56:00 | The LRRC8-mediated volume-regulated anion channel is altered in glaucoma. | 30931966 |
| 2020-09-12 16:02:00 | LRRC8/VRAC channels exhibit a noncanonical permeability to glutathione, which modulates epithelial-to-mesenchymal transition (EMT). | 31804464 |
| 2020-04-18 10:10:00 | It discusses the recent molecular biological insights into the physiology of LRRC8A as the pore-forming components of volume-regulated anion channel (VRAC) in relation to its previously proposed roles. | 31091194 |
| Type | IDs |
|---|---|
| Synonymous | AGM5, LRRC8, SWELL1 |
| Gene |
UniProtKB-ID:
LRC8A_HUMAN,
A0A024R892_HUMAN,
A8K1C7_HUMAN
UniprotKB:
Q8IWT6,
A0A024R892,
A8K1C7
UniParc:
UPI00015DA569,
UPI000004EF9E
EMBL:
BC051322,
AY358286,
AY143166,
AB037858,
AL672142,
CH471090,
AK289842,
AK074723
Ensembl:
ENSG00000136802
KO:
hsa:56262
|
| Nucleutide sequences |
EMBL-CDS:
AAN18279.1,
AAH51322.1,
BAC11161.1,
AAQ88653.1,
BAA92675.1,
EAW87842.1,
EAW87843.1,
BAF82531.1
Gene_ORFName:
UNQ221/PRO247,
hCG_1643753
Ensembl_TRS:
ENST00000372599,
ENST00000372600,
ENST00000259324
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000361680,
ENSP00000361682,
ENSP00000259324
RefSeq:
XP_005252152.1,
NP_001120717.1,
XP_011517165.1,
XP_011517166.1,
NP_062540.2,
XP_006717249.1,
XP_005252153.1,
NP_001120716.1,
XP_011517167.1
|
| Others |
UniRef100:
UniRef100_Q8IWT6,
UniRef100_A8K1C7
UniRef90:
UniRef90_A8K1C7,
UniRef90_Q8IWT6
UniRef50:
UniRef50_Q8IWT6
UniGene:
Hs.643600
CCDS:
CCDS35155.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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