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8451 CUL4A

8451

CUL4A

cullin 4A

protein-coding

Homo sapiens

基因描述

Type Description
Definition cullin 4A

研究结论

Date Results Publications
2021-03-06 13:32:00 CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy. 32466489
2020-08-22 15:30:00 Effect of CUL4A on the metastatic potential of lung adenocarcinoma to the bone. 31894344
2020-08-13 18:51:00 KDM5D inhibit epithelial-mesenchymal transition of gastric cancer through demethylation in the promoter of Cul4A in male. 30864186
2020-08-12 12:10:00 An autophagy-related (ATG) protein that plays a critical role in autophagosome biogenesis, is a direct substrate of CUL4-RING ubiquitin ligases (CRL4s). 30898011
2020-07-25 12:08:00 miR-363-3p levels were significantly decreased in tumor tissues of non-small cell lung cancer (NSCLC) patients. CUL4A mRNA and protein levels were decreased in A549 cells transfected with miR-363-3p mimics. The Dual-Luciferase reporter assay results further suggested that CUL4A represents a target gene of miR-363-3p. Decreased miR-363-3p expression enhanced gemcitabine resistance in NSCLC cells via regulation of CUL4A. 30720173

名称对应

Type IDs
Gene
UniProtKB-ID: CUL4A_HUMAN, A0A0A0MR50_HUMAN
UniprotKB: Q13619, A0A0A0MR50
UniParc: UPI000021C449, UPI0001890F81, UPI00001286A5
EMBL: AF077188, AL137002, AB178950, U58090, AL136221, AB012193, BC008308, AY365124
Ensembl: ENSG00000139842
KO: hsa:8451
Nucleutide sequences
EMBL-CDS: AAC50547.1, BAA33146.1, AAD45191.1, BAD93235.1, AAR13072.1, AAH08308.2
Ensembl_TRS: ENST00000451881, ENST00000375440, ENST00000375441, ENST00000617546, ENST00000326335
Protein sequencees
Ensembl_PRO: ENSP00000364589, ENSP00000389118, ENSP00000481782, ENSP00000364590, ENSP00000322132
RefSeq: NP_001265442.1, NP_001341868.1, NP_001341869.1, NP_001341873.1, NP_001341870.1, NP_001341872.1, NP_003580.1, NP_001008895.1, NP_001265443.1, NP_001341871.1, XP_011535825.1, NP_001341867.1
Others
UniRef100: UniRef100_A0A0A0MR50, UniRef100_Q13619
UniRef90: UniRef90_Q13619, UniRef90_A0A0A0MR50
UniRef50: UniRef50_A0A2R9AXR3, UniRef50_Q13619
UniGene: Hs.339735
CCDS: CCDS9533.1, CCDS41908.1

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