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55193 PBRM1

55193

PBRM1

polybromo 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition polybromo 1

研究结论

Date Results Publications
2021-02-27 13:52:00 Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival. 33536423
2020-11-21 13:22:00 Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer. 32396860
2020-09-19 16:28:00 A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response. 32820162
2020-04-11 11:10:00 Study identified PBRM1 as a reader for p53 acetylation on lysine 382 (K382Ac) through its bromodomain 4 (BD4). Mutations on key residues of BD4 disrupt recognition of p53 K382Ac and reduces p53 binding to promoters of target genes such as CDKN1A (p21). PBRM1 BD4 mutant fails to fully support p53 transcriptional activity and is defective as a tumor suppressor. 31863007
2019-12-07 11:24:00 Bromodomains 2, 4, and 5 of PBRM1 collaborate to generate high affinity to acetylated histone H3 lysine and tether PBRM1 to chromatin. 30585695

名称对应

Type IDs
Synonymous BAF180, PB1
Gene
UniProtKB-ID: PB1_HUMAN
UniprotKB: Q86U86
UniParc: UPI0000ECF241, UPI000013E31E, UPI00000705E4, UPI0000ECF240, UPI000019A59F, UPI0000072EF2, UPI000006EC9E, UPI000007335B, UPI00017E131B
EMBL: BC115010, BC115009, AF177387, AF225871, AF225872, AK056541, BC129935, AY281068, AF197569, BC129934, BC115011, AF225870
Ensembl: ENSG00000163939
KO: hsa:55193
Nucleutide sequences
EMBL-CDS: AAP34197.1, AAG48940.1, AAG34760.1, AAI15012.1, AAI15010.1, AAI29936.1, AAG48941.1, AAI29935.1, BAB71210.1, AAI15011.1, AAG48939.1, AAG48933.1
Ensembl_TRS: ENST00000394830, ENST00000410007, ENST00000412587, ENST00000296302, ENST00000409114, ENST00000356770, ENST00000337303, ENST00000409767, ENST00000409057
Protein sequencees
Ensembl_PRO: ENSP00000404579, ENSP00000386529, ENSP00000349213, ENSP00000338302, ENSP00000386643, ENSP00000386593, ENSP00000378307, ENSP00000296302, ENSP00000386601
RefSeq: NP_001337005.1, NP_851385.1, XP_016862224.1, XP_016862219.1, XP_016862244.1, XP_016862220.1, XP_005265339.1, XP_016862217.1, NP_001353005.1, XP_016862240.1, NP_001337004.1, XP_016862231.1, NP_001337003.1, XP_016862216.1, XP_016862241.1, XP_016862230.1, XP_016862218.1, XP_016862215.1, NP_060783.3, XP_016862229.1, NP_001353000.1, XP_011532205.1, XP_016862238.1, XP_016862233.1, XP_016862223.1, NP_001352999.1, XP_005265337.1, XP_016862253.1, NP_001337007.1, XP_016862234.1, XP_011532204.1, XP_016862232.1, NP_001353002.1, NP_001353003.1, XP_016862236.1, XP_024309386.1, XP_016862239.1, XP_016862222.1, XP_016862247.1, XP_005265336.1, NP_001337006.1, NP_001353001.1, XP_016862226.1, XP_016862214.1, XP_016862235.1, NP_001353004.1, XP_024309387.1, XP_011532202.1, XP_016862245.1, XP_016862243.1, XP_016862248.1, XP_016862227.1, XP_016862228.1, NP_001337008.1, XP_016862242.1, XP_016862221.1, XP_016862237.1, XP_016862225.1
Others
UniRef100: UniRef100_Q86U86
UniRef90: UniRef90_Q86U86
UniRef50: UniRef50_Q86U86
UniGene: Hs.189920
CCDS: CCDS2860.1, CCDS43099.1, CCDS87087.1

全选

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研究热度

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