| Type | Description |
|---|---|
| Definition | DNA polymerase alpha 1, catalytic subunit |
| Date | Results | Publications |
|---|---|---|
| 2020-02-08 10:30:00 | Defective alpha-Primase Leads to X-Linked Intellectual Disability Associated with Severe Growth Retardation, Microcephaly, and Hypogonadism. | 31006512 |
| 2019-02-02 12:07:00 | detailed structural comparison of Polalpha with other replicative DNA polymerases disclosed common features and some differences, which may reflect the specialization of each polymerase in genome replication | 29555682 |
| 2017-08-19 10:42:00 | High POLA1 expression is associated with bladder cancer. | 28320388 |
| 2017-05-20 10:16:00 | Divalent ions attenuate DNA synthesis by human DNA polymerase alpha by changing the structure of the template/primer or by perturbing the polymerase reaction. | 27235627 |
| 2017-05-13 19:31:00 | We propose that completely skewed XCI favoring the normal X chromosome resulted from death of cells with an active derivative X that was caused by a non-functional POLA1 gene. In summary, we conclude that functional monosomy of 6q27-qter and functional disomy of Xpter-p22.11 are responsible for the clinical phenotype of the patient | 28371302 |
| Type | IDs |
|---|---|
| Synonymous | NSX, POLA, p180 |
| Gene |
UniProtKB-ID:
DPOLA_HUMAN,
A6NMQ1_HUMAN
UniprotKB:
P09884,
A6NMQ1
UniParc:
UPI000022DD18,
UPI000014D383
EMBL:
AC002504,
M64481,
KF459037,
AC004655,
X06745,
AC135280,
KF459032,
AY275833,
AC079375
Ensembl:
ENSG00000101868
KO:
hsa:5422
|
| Nucleutide sequences |
EMBL-CDS:
AAA52318.1,
AAP13534.1,
CAA29920.1
Ensembl_TRS:
ENST00000379059,
ENST00000379068
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000368349,
ENSP00000368358
RefSeq:
XP_016885085.1,
NP_058633.2,
XP_016885084.1,
XP_011543843.1,
XP_006724562.1,
NP_001365232.1,
XP_024308160.1,
XP_011543842.1,
NP_001317289.1,
XP_016885083.1
|
| Others |
UniRef100:
UniRef100_A6NMQ1,
UniRef100_P09884
UniRef90:
UniRef90_P09884
UniRef50:
UniRef50_P09884
UniGene:
Hs.567319
CCDS:
CCDS14214.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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