| Type | Description |
|---|---|
| Definition | SEC31 homolog A, COPII coat complex component |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 11:33:00 | We demonstrate through human and Drosophila genetic and in vitro molecular studies, that a severe neurological syndrome is caused by a null mutation in SEC31A, reducing cell viability through enhanced ER-stress response, in line with SEC31A's role in the COP-II complex. | 30464055 |
| 2018-10-13 11:28:00 | USP8 deubiquitinates Sec31A and inhibits the formation of large COPII carriers, thereby suppressing collagen IV secretion. | 29604273 |
| 2015-10-03 11:18:00 | Results show the crystal structure of the complex between ALG-2 and a peptide of Sec31A and found that the peptide binds to the third hydrophobic pocket (Pocket 3) and that ALG-2 recognizing 2 types of motifs at different hydrophobic surfaces of Sec31A. | 25667979 |
| 2015-05-09 12:38:00 | findings suggest that AnxA11 maintains architectural and functional features of the ERES by coordinating with ALG-2 to stabilize Sec31A at the ERES. | 25540196 |
| 2014-12-20 10:47:00 | ALG-2/Sec31A interactions were not required for the localization of Sec31A to ER exit sites per se but appeared to acutely regulate the stability and trafficking of the cargo receptor p24 and the distribution of the vesicle tether protein p115 | 25006245 |
| Type | IDs |
|---|---|
| Synonymous | ABP125, ABP130, HSPC275, HSPC334, SEC31L1 |
| Gene |
UniProtKB-ID:
SC31A_HUMAN,
A1LU61_HUMAN,
A0A024RDH6_HUMAN
UniprotKB:
O94979,
A1LU61,
A0A024RDH6
UniParc:
UPI000156546C,
UPI000044FDDE,
UPI0000D4A54B,
UPI000013D50D,
UPI000003E7E1,
UPI000000DC6C,
UPI000189A77A,
UPI000156546B,
UPI0001D3B545,
UPI000156546A
EMBL:
AK295810,
BC084583,
AC021105,
AK125897,
AF139184,
AF161452,
AL049463,
BC143492,
BC143489,
AB018358,
AF161393,
AC108469,
BC143491,
CH471057,
CR933696,
AB020712,
AB018359,
BC117221,
BC047883,
AY137583
Ensembl:
ENSG00000138674
KO:
hsa:22872
|
| Nucleutide sequences |
EMBL-CDS:
AAI43492.1,
AAH47883.1,
BAC86336.1,
AAI17222.1,
CAH56418.1,
AAI43490.1,
AAH84583.1,
AAF29012.1,
CAI45995.1,
AAN15221.1,
BAA84923.1,
EAX05908.1,
AAF67836.1,
BAA84924.1,
AAI43493.1,
BAA74928.2,
BAG58628.1,
AAF28953.1,
EAX05909.1,
EAX05912.1,
EAX05907.1,
EAX05910.1
Gene_ORFName:
HSPC334,
HSPC275,
hCG_20214,
hCG_20214
Ensembl_TRS:
ENST00000443462,
ENST00000448323,
ENST00000348405,
ENST00000311785,
ENST00000395310,
ENST00000513858,
ENST00000505984,
ENST00000500777,
ENST00000509142,
ENST00000508502,
ENST00000355196
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000426886,
ENSP00000408027,
ENSP00000347329,
ENSP00000424635,
ENSP00000378721,
ENSP00000337602,
ENSP00000309070,
ENSP00000400926,
ENSP00000421464,
ENSP00000426569,
ENSP00000424451
RefSeq:
NP_001287674.1,
NP_057295.2,
NP_001305048.1,
NP_001177978.1,
NP_001070676.1,
NP_001287673.1,
NP_001070674.1,
NP_001305049.1,
NP_001070675.1
|
| Others |
UniRef100:
UniRef100_O94979,
UniRef100_A0A024RDH6
UniRef90:
UniRef90_H2PDS2,
UniRef90_O94979
UniRef50:
UniRef50_O94979
UniGene:
Hs.370024
CCDS:
CCDS75155.1,
CCDS75156.1,
CCDS54773.1,
CCDS47088.1,
CCDS3597.1,
CCDS3596.1,
CCDS43244.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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