| Type | Description |
|---|---|
| Definition | UBX domain protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-06-29 11:48:00 | Our results identify how VCP is specifically targeted to ubiquitylated substrates in the BAG6 triage pathway and suggest that the degradation of ubiquitylated clients by the proteasome is reliant on the association of UBXN1 with ubiquitylated substrates and the catalytic activity of VCP. | 29685906 |
| 2017-08-05 10:09:00 | The ability of UBXN1 and other family members to negatively regulate the NFkappaB pathway may be important for dampening the host immune response in disease processes and also re-activating quiescent HIV from latent viral reservoirs in chronically infected individuals | 28152074 |
| 2017-02-18 10:11:00 | p47 promotes, whereas SASK1 delays the degradation of a single ERAD substrate, alpha-TCR. Additionally, we found that SAKS1 selectively inhibits the degradation of ERAD substrates without affecting cytosolic proteasomal substrates. | 27785701 |
| 2015-06-20 12:42:00 | UBXN1 is a negative regulator of NF-kappaB signaling. | 25681446 |
| 2013-11-16 10:19:00 | UBXN1 is induced and recruited to MAVS after virus infection, serving as a brake to prevent excessive RLR signaling, most likely at a late stage of infection. | 23545497 |
| Type | IDs |
|---|---|
| Synonymous | 2B28, SAKS1, UBXD10 |
| Gene |
UniProtKB-ID:
UBXN1_HUMAN,
A0A024R539_HUMAN,
A0A024R598_HUMAN,
A0A087WTZ5_HUMAN
UniprotKB:
Q04323,
A0A024R539,
A0A024R598,
A0A087WTZ5
UniParc:
UPI0000E22AED,
UPI0000073CEA,
UPI000006DE59
EMBL:
CH471076,
BC040129,
BC000902,
BC001372,
M68864,
AP001458
Ensembl:
ENSG00000162191
KO:
hsa:51035
|
| Nucleutide sequences |
EMBL-CDS:
AAA36396.1,
AAH01372.1,
AAH00902.1,
AAH40129.1,
EAW74067.1,
EAW74063.1,
EAW74064.1,
EAW74061.1
Gene_ORFName:
hCG_1818009,
hCG_1818009
Ensembl_TRS:
ENST00000294119,
ENST00000301935,
ENST00000616865
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000303991,
ENSP00000294119,
ENSP00000478250
RefSeq:
NP_001273006.1,
NP_056937.2,
XP_016873363.1,
NP_001273007.1,
XP_005274090.1
|
| Others |
UniRef100:
UniRef100_A0A024R539,
UniRef100_A0A087WTZ5,
UniRef100_Q04323
UniRef90:
UniRef90_A0A087WTZ5,
UniRef90_Q04323,
UniRef90_A0A096MLK4
UniRef50:
UniRef50_A0A096MLK4,
UniRef50_H0V3W0,
UniRef50_Q04323
UniGene:
Hs.351296
CCDS:
CCDS8029.1,
CCDS66105.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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