| Type | Description |
|---|---|
| Definition | triokinase and FMN cyclase |
| Date | Results | Publications |
|---|---|---|
| 2020-04-18 10:19:00 | Bi-allelic Variants in TKFC Encoding Triokinase/FMN Cyclase Are Associated with Cataracts and Multisystem Disease. | 32004446 |
| 2014-07-12 10:52:00 | The peptide fragment (m/z 520.3) of DAK is a promising biomarker to guide timing of antiviral treatment and to avoid liver biopsy in compensated chronic hepatitis B patients. | 24289155 |
| 2014-06-21 13:01:00 | analysis of human triokinase/FMN cyclase reveals that kinase activity requires intact homodimers, but cyclase requires only a truncated, single domain subunit | 24569995 |
| 2010-01-21 00:00:00 | DAK, the physiological suppressor of cytoplasmic viral RNA sensor MDA5, specifically inhibits MDA5- but not RNA helicase RIG-I-mediated innate antiviral signaling. | 17600090 |
| 2010-01-21 00:00:00 | Evidence supports that a single protein sustains both FMN cyclase and ATP-dependent Dha kinase activities, probably in a single active center | 16289032 |
| Type | IDs |
|---|---|
| Synonymous | DAK, NET45 |
| Gene |
UniProtKB-ID:
TKFC_HUMAN,
A0A140VJH7_HUMAN
UniprotKB:
Q3LXA3,
A0A140VJH7
UniParc:
UPI00000718B9,
UPI0000E22ABA
EMBL:
BC001341,
HM005364,
AK023915,
DQ138290,
AP003108,
DQ344550,
AK223580
Ensembl:
ENSG00000149476
KO:
hsa:26007
|
| Nucleutide sequences |
EMBL-CDS:
AAH01341.1,
BAD97300.1,
BAB14722.1,
ABA10576.1,
ABC70184.1,
AEE60964.1
Ensembl_TRS:
ENST00000394900
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000378360
RefSeq:
NP_001338907.1,
XP_016873006.1,
NP_001338908.1,
XP_011543214.1,
NP_001338909.1,
XP_016873007.1,
NP_001338906.1,
XP_016873009.1,
NP_056348.2,
XP_016873008.1,
NP_001338905.1
|
| Others |
UniRef100:
UniRef100_Q3LXA3
UniRef90:
UniRef90_Q3LXA3
UniRef50:
UniRef50_Q3LXA3
UniGene:
Hs.6278
CCDS:
CCDS8003.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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