| Type | Description |
|---|---|
| Definition | dyskerin pseudouridine synthase 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-28 19:06:00 | The nucleolar-related protein Dyskerin pseudouridine synthase 1 (DKC1) predicts poor prognosis in breast cancer. | 32868896 |
| 2021-02-27 13:48:00 | Comparable Effects of the Androgen Derivatives Danazol, Oxymetholone and Nandrolone on Telomerase Activity in Human Primary Hematopoietic Cells from Patients with Dyskeratosis Congenita. | 33003434 |
| 2021-01-09 13:33:00 | Acute depletion of telomerase components DKC1 and NOP10 induces oxidative stress and disrupts ribosomal biogenesis via NPM1 and activation of the P53 pathway. | 32910990 |
| 2020-10-24 14:10:00 | Pseudouridylation defect due to DKC1 and NOP10 mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis. | 32554502 |
| 2020-10-24 13:59:00 | DKC1 enhances angiogenesis by promoting HIF-1alpha transcription and facilitates metastasis in colorectal cancer. | 31857720 |
| Type | IDs |
|---|---|
| Synonymous | CBF5, DKC, DKCX, NAP57, NOLA4, XAP101 |
| Gene |
UniProtKB-ID:
DKC1_HUMAN
UniprotKB:
O60832
UniParc:
UPI00000325ED,
UPI000041845D
EMBL:
AF067008,
BC009928,
AJ010395,
AF067013,
U59151,
JF279874,
AF067022,
AF067023,
AJ010396,
AF067015,
AF067010,
BC010015,
AF067021,
AF067012,
AF067016,
AF067017,
AF067009,
AF067014,
AC109993,
AF067011,
AF067019,
AF067020,
AF067018,
AJ224481
Ensembl:
ENSG00000130826
KO:
hsa:1736
|
| Nucleutide sequences |
EMBL-CDS:
CAA11970.1,
AAD11815.1,
AAH09928.1,
CAB51168.1,
AAB94299.1,
AAH10015.1,
AAD20232.1,
ADX66370.1
Ensembl_TRS:
ENST00000620277,
ENST00000369550
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000358563,
ENSP00000478387
RefSeq:
NP_001135935.1,
NP_001275676.1,
NP_001354.1
|
| Others |
UniRef100:
UniRef100_O60832
UniRef90:
UniRef90_O60832
UniRef50:
UniRef50_O60832
UniGene:
Hs.4747
CCDS:
CCDS14761.1,
CCDS76062.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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